Multiple memory traces for olfactory reward learning in drosophila

Thum, Andreas; Jenett, Arnim; Ito, Kei; Heisenberg, Martin; Tanimoto, Hiromu

Multiple memory traces for olfactory reward learning in drosophila

Files

Thum.pdf(229.21 KB)

Date

2007

Authors

Thum, Andreas

Jenett, Arnim

Ito, Kei

Heisenberg, Martin

Tanimoto, Hiromu

Publication type

Journal article

Published in

Journal of Neuroscience ; 27 (2007), 41. - pp. 11132-11138. - ISSN 0270-6474. - eISSN 1529-2401

Abstract

Physical traces underlying simple memories can be confined to a single group of cells in the brain. In the fly Drosophila melanogaster, the Kenyon cells of the mushroom bodies house traces for both appetitive and aversive odor memories. The adenylate cyclase protein, Rutabaga, has been shown to mediate both traces. Here, we show that, for appetitive learning, another group of cells can additionally accommodate a Rutabaga-dependent memory trace. Localized expression of rutabaga in either projection neurons, the first-order olfactory interneurons, or in Kenyon cells, the second-order interneurons, is sufficient for rescuing the mutant defect in appetitive short-term memory. Thus, appetitive learning may induce multiple memory traces in the first- and second-order olfactory interneurons using the same plasticity mechanism. In contrast, aversive odor memory of rutabaga is rescued selectively in the Kenyon cells, but not in the projection neurons. This difference in the organization of memory traces is consistent with the internal representation of reward and punishment.

Subject (DDC)

570 Biosciences, Biology

Keywords

learning,memory,insect,memory trace,olfaction,adenylate cyclase

Cite This

ISO 690

THUM, Andreas, Arnim JENETT, Kei ITO, Martin HEISENBERG, Hiromu TANIMOTO, 2007. Multiple memory traces for olfactory reward learning in drosophila. In: Journal of Neuroscience. 27(41), pp. 11132-11138. ISSN 0270-6474. eISSN 1529-2401. Available under: doi: 10.1523/JNEUROSCI.2712-07.2007

BibTex

@article{Thum2007Multi-16889,
  year={2007},
  doi={10.1523/JNEUROSCI.2712-07.2007},
  title={Multiple memory traces for olfactory reward learning in drosophila},
  number={41},
  volume={27},
  issn={0270-6474},
  journal={Journal of Neuroscience},
  pages={11132--11138},
  author={Thum, Andreas and Jenett, Arnim and Ito, Kei and Heisenberg, Martin and Tanimoto, Hiromu}
}

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