Revolutionizing developmental neurotoxicity testing : a journey from animal models to advanced in vitro systems

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2024
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Smirnova, Lena
Hogberg, Helena T.
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Institutionen der Bundesrepublik Deutschland: 161L0243B
Institutionen der Bundesrepublik Deutschland: 016LW0146K
European Union (EU): 964537
European Union (EU): 964518
European Union (EU): 963845
European Union (EU): 101057014
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PARC: Partnership for the Assessment of Risks from Chemicals
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Alternatives to Animal Experimentation : ALTEX. ALTEX Edition. 2024, 41(2), pp. 152-178. ISSN 1868-596X. Available under: doi: 10.14573/altex.2403281
Zusammenfassung

Developmental neurotoxicity (DNT) testing has seen enormous progress over the last two decades. Preceding even the publication of the animal-based OECD test guideline for DNT testing in 2007, a series of non-animal technology workshops and conferences that started in 2005 has shaped a community that has delivered a comprehensive battery of in vitro test methods (DNT IVB). Its data interpretation is now covered by a very recent OECD guidance (No. 377). Here, we overview the progress in the field, focusing on the evolution of testing strategies, the role of emerging technol­ogies, and the impact of OECD test guidelines on DNT testing. In particular, this is an example of the targeted development of an animal-free testing approach for one of the most complex hazards of chemicals to human health. These developments started literally from a blank slate, with no proposed alternative methods available. Over two decades, cutting-edge science enabled the design of a testing approach that spares animals and enables throughput to address this challenging hazard. While it is evident that the field needs guidance and regulation, the massive economic impact of decreased human cognitive capacity caused by chemical exposure should be prioritized more highly. Beyond this, the claim to fame of DNT in vitro testing is the enormous scientific progress it has brought for understanding the human brain, its development, and how it can be perturbed.

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570 Biowissenschaften, Biologie
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ISO 690SMIRNOVA, Lena, Helena T. HOGBERG, Marcel LEIST, Thomas HARTUNG, 2024. Revolutionizing developmental neurotoxicity testing : a journey from animal models to advanced in vitro systems. In: Alternatives to Animal Experimentation : ALTEX. ALTEX Edition. 2024, 41(2), pp. 152-178. ISSN 1868-596X. Available under: doi: 10.14573/altex.2403281
BibTex
@article{Smirnova2024Revol-69784,
  year={2024},
  doi={10.14573/altex.2403281},
  title={Revolutionizing developmental neurotoxicity testing : a journey from animal models to advanced in vitro systems},
  number={2},
  volume={41},
  issn={1868-596X},
  journal={Alternatives to Animal Experimentation : ALTEX},
  pages={152--178},
  author={Smirnova, Lena and Hogberg, Helena T. and Leist, Marcel and Hartung, Thomas}
}
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