Asymmetry of Drosophila ON and OFF motion detectors enhances real-world velocity estimation

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2016
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Leonhardt, Aljoscha
Ammer, Georg
Meier, Matthias
Serbe, Etienne
Borst, Alexander
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The reliable estimation of motion across varied surroundings represents a survival-critical task for sighted animals. How neural circuits have adapted to the particular demands of natural environments, however, is not well understood. We explored this question in the visual system of Drosophila melanogaster. Here, as in many mammalian retinas, motion is computed in parallel streams for brightness increments (ON) and decrements (OFF). When genetically isolated, ON and OFF pathways proved equally capable of accurately matching walking responses to realistic motion. To our surprise, detailed characterization of their functional tuning properties through in vivo calcium imaging and electrophysiology revealed stark differences in temporal tuning between ON and OFF channels. We trained an in silico motion estimation model on natural scenes and discovered that our optimized detector exhibited differences similar to those of the biological system. Thus, functional ON-OFF asymmetries in fly visual circuitry may reflect ON-OFF asymmetries in natural environments.

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ISO 690LEONHARDT, Aljoscha, Georg AMMER, Matthias MEIER, Etienne SERBE, Armin BAHL, Alexander BORST, 2016. Asymmetry of Drosophila ON and OFF motion detectors enhances real-world velocity estimation. In: Nature Neuroscience. Nature Publishing Group. 2016, 19(5), pp. 706-715. ISSN 1097-6256. eISSN 1546-1726. Available under: doi: 10.1038/nn.4262
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@article{Leonhardt2016Asymm-53683,
  year={2016},
  doi={10.1038/nn.4262},
  title={Asymmetry of Drosophila ON and OFF motion detectors enhances real-world velocity estimation},
  number={5},
  volume={19},
  issn={1097-6256},
  journal={Nature Neuroscience},
  pages={706--715},
  author={Leonhardt, Aljoscha and Ammer, Georg and Meier, Matthias and Serbe, Etienne and Bahl, Armin and Borst, Alexander}
}
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