Nicotine withdrawal alters neural responses to psychosocial stress

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2016
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Ashare, Rebecca L.
Lerman, Caryn
Cao, Wen
Falcone, Mary
Bernardo, Leah
Ruparel, Kosha
Hopson, Ryan
Gur, Ruben
Loughead, James
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Psychopharmacology. 2016, 233(13), pp. 2459-2467. ISSN 0033-3158. eISSN 1432-2072. Available under: doi: 10.1007/s00213-016-4299-5
Zusammenfassung

Introduction

Psychosocial stress is considered to be an important mechanism underlying smoking behavior and relapse. Thus, understanding the effects of acute nicotine withdrawal on responses to stress is important to intervene to prevent stress-induced relapse. The current study investigated the neural correlates of psychosocial stress during acute nicotine withdrawal in chronic smokers.

Methods

Thirty-nine treatment-seeking smokers were randomized to one of two conditions (abstinent 24 h (n = 21) or smoking as usual (n = 18)). They were then exposed to the Montreal Imaging Stress Task (MIST), a psychosocial stress task consisting of difficult mental arithmetic problems while receiving negative performance feedback while undergoing functional magnetic resonance imaging (fMRI).

Results

Subjective measures of stress increased following the MIST, compared to baseline. Whole brain between-group analysis identified significant activation clusters in four regions for the stress induction minus control contrast: inferior frontal gyrus (IFG), anterior/para cingulate cortex (ACC), precuneus, and supramarginal gyrus (SMG). In all regions, the deprived group showed significantly greater activation compared to the non-deprived group. No significant correlations were found between subjective stress and BOLD signal activation (ps > 0.07).

Conclusions

This study provides new evidence that brain regions previously shown to be predictive of relapse, such as the precuneus and IFG, display heightened neural responses to stress during nicotine deprivation. These data identify the brain regions that may be associated with withdrawal-related stress responses. Increased stress-related activation during nicotine withdrawal may identify those most vulnerable to relapse and represent a target for novel pharmacological intervention.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
Nicotine, Withdrawal, Smoking, Stress, fMRI, Imaging
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ISO 690ASHARE, Rebecca L., Caryn LERMAN, Wen CAO, Mary FALCONE, Leah BERNARDO, Kosha RUPAREL, Ryan HOPSON, Ruben GUR, Jens C. PRUESSNER, James LOUGHEAD, 2016. Nicotine withdrawal alters neural responses to psychosocial stress. In: Psychopharmacology. 2016, 233(13), pp. 2459-2467. ISSN 0033-3158. eISSN 1432-2072. Available under: doi: 10.1007/s00213-016-4299-5
BibTex
@article{Ashare2016-07Nicot-38174,
  year={2016},
  doi={10.1007/s00213-016-4299-5},
  title={Nicotine withdrawal alters neural responses to psychosocial stress},
  number={13},
  volume={233},
  issn={0033-3158},
  journal={Psychopharmacology},
  pages={2459--2467},
  author={Ashare, Rebecca L. and Lerman, Caryn and Cao, Wen and Falcone, Mary and Bernardo, Leah and Ruparel, Kosha and Hopson, Ryan and Gur, Ruben and Pruessner, Jens C. and Loughead, James}
}
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