No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder

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2015
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Hernaus, Dennis
Collip, Dina
Kasanova, Zuzana
Winz, Oliver
Heinzel, Alexander
van Amelsvoort, Therese
Shali, Siamak Mohammadkhani
Booij, Jan
Myin-Germeys, Inez
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Translational Psychiatry. 2015, 5, e547. eISSN 2158-3188. Available under: doi: 10.1038/tp.2015.37
Zusammenfassung

Stress is an important risk factor in the etiology of psychotic disorder. Preclinical work has shown that stress primarily increases dopamine (DA) transmission in the frontal cortex. Given that DA-mediated hypofrontality is hypothesized to be a cardinal feature of psychotic disorder, stress-related extrastriatal DA release may be altered in psychotic disorder. Here we quantified for the first time stress-induced extrastriatal DA release and the spatial extent of extrastriatal DA release in individuals with non-affective psychotic disorder (NAPD). Twelve healthy volunteers (HV) and 12 matched drug-free NAPD patients underwent a single infusion [(18)F]fallypride positron emission tomography scan during which they completed the control and stress condition of the Montreal Imaging Stress Task. HV and NAPD did not differ in stress-induced [(18)F]fallypride displacement and the spatial extent of stress-induced [(18)F]fallypride displacement in medial prefrontal cortex (mPFC) and temporal cortex (TC). In the whole sample, the spatial extent of stress-induced radioligand displacement in right ventro-mPFC, but not dorso-mPFC or TC, was positively associated with task-induced subjective stress. Psychotic symptoms during the scan or negative, positive and general subscales of the Positive and Negative Syndrome Scale were not associated with stress-induced [(18)F]fallypride displacement nor the spatial extent of stress-induced [(18)F]fallypride displacement in NAPD. Our results do not offer evidence for altered stress-induced extrastriatal DA signaling in NAPD, nor altered functional relevance. The implications of these findings for the role of the DA system in NAPD and stress processing are discussed.

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ISO 690HERNAUS, Dennis, Dina COLLIP, Zuzana KASANOVA, Oliver WINZ, Alexander HEINZEL, Therese VAN AMELSVOORT, Siamak Mohammadkhani SHALI, Jan BOOIJ, Jens C. PRUESSNER, Inez MYIN-GERMEYS, 2015. No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder. In: Translational Psychiatry. 2015, 5, e547. eISSN 2158-3188. Available under: doi: 10.1038/tp.2015.37
BibTex
@article{Hernaus2015-04-14evide-38497,
  year={2015},
  doi={10.1038/tp.2015.37},
  title={No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder},
  volume={5},
  journal={Translational Psychiatry},
  author={Hernaus, Dennis and Collip, Dina and Kasanova, Zuzana and Winz, Oliver and Heinzel, Alexander and van Amelsvoort, Therese and Shali, Siamak Mohammadkhani and Booij, Jan and Pruessner, Jens C. and Myin-Germeys, Inez},
  note={Article Number: e547}
}
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