@article{Sonnemann1998-10-15Disse-49755,
  year={1998},
  doi={10.1016/S0014-5793(98)01139-9},
  title={Dissection of the cAMP induced cytosolic calcium response in Dictyostelium discoideum : the role of cAMP receptor subtypes and G protein subunits},
  number={2},
  volume={436},
  issn={0014-5793},
  journal={FEBS Letters},
  pages={271--276},
  author={Sonnemann, Jürgen and Aichem, Annette and Schlatterer, Christina}
}

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    <dcterms:abstract xml:lang="eng">The cAMP signaling cascade leading to changes in [Ca&lt;sup&gt;2+&lt;/sup&gt;]&lt;sub&gt;i&lt;/sub&gt; in Dictyostelium discoideum was analyzed using cell lines overexpressing single cAMP receptor subtypes (cAR1–cAR3) or lacking the G&lt;sub&gt;α2&lt;/sub&gt; or G&lt;sub&gt;β&lt;/sub&gt; subunit of the G protein. Imaging of fura2‐dextran‐loaded amoebae revealed cAMP‐induced [Ca&lt;sup&gt;2+&lt;/sup&gt;]&lt;sub&gt;i&lt;/sub&gt; changes characteristic for each receptor subtype activated. Cells expressing distinct subtypes sort to defined zones during multicellular development suggesting involvement of the specific [Ca&lt;sup&gt;2+&lt;/sup&gt;]&lt;sub&gt;i&lt;/sub&gt; transients in patterning processes. Whereas generation of the [Ca&lt;sup&gt;2+&lt;/sup&gt;]&lt;sub&gt;i&lt;/sub&gt; increase was G&lt;sub&gt;α2&lt;/sub&gt;‐independent, only few cells devoid of G&lt;sub&gt;β&lt;/sub&gt; displayed a [Ca&lt;sup&gt;2+&lt;/sup&gt;]&lt;sub&gt;i&lt;/sub&gt; change after stimulation indicating its participation in the regulation of the calcium homeostasis.</dcterms:abstract>
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    <dcterms:title>Dissection of the cAMP induced cytosolic calcium response in Dictyostelium discoideum : the role of cAMP receptor subtypes and G protein subunits</dcterms:title>
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    <dc:contributor>Schlatterer, Christina</dc:contributor>
    <dc:contributor>Aichem, Annette</dc:contributor>
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    <dc:creator>Sonnemann, Jürgen</dc:creator>
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