Dissection of the cAMP induced cytosolic calcium response in Dictyostelium discoideum : the role of cAMP receptor subtypes and G protein subunits

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1998
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The cAMP signaling cascade leading to changes in [Ca2+]i in Dictyostelium discoideum was analyzed using cell lines overexpressing single cAMP receptor subtypes (cAR1–cAR3) or lacking the Gα2 or Gβ subunit of the G protein. Imaging of fura2‐dextran‐loaded amoebae revealed cAMP‐induced [Ca2+]i changes characteristic for each receptor subtype activated. Cells expressing distinct subtypes sort to defined zones during multicellular development suggesting involvement of the specific [Ca2+]i transients in patterning processes. Whereas generation of the [Ca2+]i increase was Gα2‐independent, only few cells devoid of Gβ displayed a [Ca2+]i change after stimulation indicating its participation in the regulation of the calcium homeostasis.

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ISO 690SONNEMANN, Jürgen, Annette AICHEM, Christina SCHLATTERER, 1998. Dissection of the cAMP induced cytosolic calcium response in Dictyostelium discoideum : the role of cAMP receptor subtypes and G protein subunits. In: FEBS Letters. Wiley. 1998, 436(2), pp. 271-276. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1016/S0014-5793(98)01139-9
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@article{Sonnemann1998-10-15Disse-49755,
  year={1998},
  doi={10.1016/S0014-5793(98)01139-9},
  title={Dissection of the cAMP induced cytosolic calcium response in Dictyostelium discoideum : the role of cAMP receptor subtypes and G protein subunits},
  number={2},
  volume={436},
  issn={0014-5793},
  journal={FEBS Letters},
  pages={271--276},
  author={Sonnemann, Jürgen and Aichem, Annette and Schlatterer, Christina}
}
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