@article{Kuraku2009Timin-6731,
  year={2009},
  doi={10.1093/molbev/msn222},
  title={Timing of Genome Duplications Relative to the Origin of the Vertebrates : Did CycIostomes Diverge before or after?},
  number={1},
  volume={26},
  issn={0737-4038},
  journal={Molecular Biology and Evolution},
  pages={47--59},
  author={Kuraku, Shigehiro and Meyer, Axel and Kuratani, Shigeru}
}

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    <dc:creator>Kuratani, Shigeru</dc:creator>
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    <dcterms:abstract xml:lang="eng">Two rounds of whole-genome duplications are thought to have played an important role in the establishment of gene repertoires in vertebrates. These events occurred during chordate evolution after the split of the urochordate and cephalochordate lineages but before the radiation of extant gnathostomes (jawed vertebrates). During this interval, diverse agnathans (jawless fishes), including cyclostomes (hagfishes and lampreys), diverged. However, there is no solid evidence for the timing of these genome duplications in relation to the divergence of cyclostomes from the gnathostome lineage. We conducted cDNA sequencing in diverse early vertebrates for members of homeobox-containing (DIx and ParaHox) and other gene families that would serve as landmarks for genome duplications. Including these new sequences, we performed a molecular phylogenetic census using the maximum likelihood method for 55 gene families. In most of these gene families, we detected many more gene duplications before the cycIostome-gnathostome split, than after. Many of these gene families (e.g., visual opsins, RAR, Notch) have multiple paralogs in conserved, syntenic genomic regions that must have been generated by large-scale duplication events. Taken together, this indicates that the genome duplications occurted before the cyclostome-gnathostome split. We propose that the redundancy in gene repertoires possessed by all vertebrates, including hagfishes and lampreys, was introduced primarily by genome duplications. Apart from subsequent lineage-specific modifications, these ancient genome duplication events might serve generally to distinguish vertebrates from invertebrates at the genomic level.</dcterms:abstract>
    <dc:contributor>Kuraku, Shigehiro</dc:contributor>
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    <dcterms:bibliographicCitation>First publ. in: Molecular Biology and Evolution 26 (2009), pp. 47-59</dcterms:bibliographicCitation>
    <dcterms:issued>2009</dcterms:issued>
    <dc:creator>Meyer, Axel</dc:creator>
    <dcterms:title>Timing of Genome Duplications Relative to the Origin of the Vertebrates : Did CycIostomes Diverge before or after?</dcterms:title>
    <dc:creator>Kuraku, Shigehiro</dc:creator>
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    <dc:contributor>Kuratani, Shigeru</dc:contributor>
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