Aptamers in RNA-based switches of gene expression
Aptamers in RNA-based switches of gene expression
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2020
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Current Opinion in Biotechnology ; 63 (2020). - pp. 34-40. - Elsevier. - ISSN 0958-1669. - eISSN 1879-0429
Abstract
The ability to control gene expression via small molecule effectors is important in basic research as well as in future gene therapy applications. Although transcription factor-based systems are widely used, they are not well suited for certain applications due to a lack of functionality, limited available coding space, and potential immunogenicity of the regulatory proteins. RNA-based switches fill this gap since they can be designed to respond to effector compounds utilizing ligand-sensing aptamers. These systems are very modular since the aptamer can be combined with a variety of different expression platforms. RNA-based switches have been constructed that allow for controlling gene expression in diverse contexts. Here we discuss latest developments and applications of aptamer-based gene expression switches in eukaryotes.
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SPÖRING, Maike, Monika FINKE, Jörg S. HARTIG, 2020. Aptamers in RNA-based switches of gene expression. In: Current Opinion in Biotechnology. Elsevier. 63, pp. 34-40. ISSN 0958-1669. eISSN 1879-0429. Available under: doi: 10.1016/j.copbio.2019.11.008BibTex
@article{Sporing2020Aptam-48223, year={2020}, doi={10.1016/j.copbio.2019.11.008}, title={Aptamers in RNA-based switches of gene expression}, volume={63}, issn={0958-1669}, journal={Current Opinion in Biotechnology}, pages={34--40}, author={Spöring, Maike and Finke, Monika and Hartig, Jörg S.} }
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