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Aptamers in RNA-based switches of gene expression

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2020

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https://doi.org/10.1016/j.copbio.2019.11.008
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Current Opinion in Biotechnology. Elsevier. 2020, 63, pp. 34-40. ISSN 0958-1669. eISSN 1879-0429. Available under: doi: 10.1016/j.copbio.2019.11.008

Zusammenfassung

The ability to control gene expression via small molecule effectors is important in basic research as well as in future gene therapy applications. Although transcription factor-based systems are widely used, they are not well suited for certain applications due to a lack of functionality, limited available coding space, and potential immunogenicity of the regulatory proteins. RNA-based switches fill this gap since they can be designed to respond to effector compounds utilizing ligand-sensing aptamers. These systems are very modular since the aptamer can be combined with a variety of different expression platforms. RNA-based switches have been constructed that allow for controlling gene expression in diverse contexts. Here we discuss latest developments and applications of aptamer-based gene expression switches in eukaryotes.

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ISO 690SPÖRING, Maike, Monika FINKE, Jörg S. HARTIG, 2020. Aptamers in RNA-based switches of gene expression. In: Current Opinion in Biotechnology. Elsevier. 2020, 63, pp. 34-40. ISSN 0958-1669. eISSN 1879-0429. Available under: doi: 10.1016/j.copbio.2019.11.008
BibTex
@article{Sporing2020Aptam-48223,
  year={2020},
  doi={10.1016/j.copbio.2019.11.008},
  title={Aptamers in RNA-based switches of gene expression},
  volume={63},
  issn={0958-1669},
  journal={Current Opinion in Biotechnology},
  pages={34--40},
  author={Spöring, Maike and Finke, Monika and Hartig, Jörg S.}
}
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