Publikation: BAP1 in cancer : epigenetic stability and genome integrity
Lade...
Dateien
Datum
2022
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Gold
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Discover Oncology. Springer. 2022, 13(1), 117. eISSN 2730-6011. Available under: doi: 10.1007/s12672-022-00579-x
Zusammenfassung
Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display hypersusceptibility to exposure-associated cancers, such as asbestos-driven mesothelioma, thus BAP1 status has been postulated to participate in gene-environment interaction. Intriguingly, BAP1 functions display also a high degree of tissue dependency, associated to a peculiar cancer spectrum and cell types of specific functions. Mechanistically, BAP1 functions as an ubiquitin carboxy-terminal hydrolase (UCH) and controls regulatory ubiquitination of histones as well as degradative ubiquitination of a range of protein substrates. In this article we provide an overview of the most relevant findings on BAP1, underpinning its tissue specific tumour suppressor function. We also discuss the importance of its epigenetic role versus the control of protein stability in the regulation of genomic integrity.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
CAPORALI, Sabrina, Alessio BUTERA, Ivano AMELIO, 2022. BAP1 in cancer : epigenetic stability and genome integrity. In: Discover Oncology. Springer. 2022, 13(1), 117. eISSN 2730-6011. Available under: doi: 10.1007/s12672-022-00579-xBibTex
@article{Caporali2022-11-01cance-59306,
year={2022},
doi={10.1007/s12672-022-00579-x},
title={BAP1 in cancer : epigenetic stability and genome integrity},
number={1},
volume={13},
journal={Discover Oncology},
author={Caporali, Sabrina and Butera, Alessio and Amelio, Ivano},
note={Article Number: 117}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/59306">
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dc:contributor>Amelio, Ivano</dc:contributor>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dc:rights>Attribution 4.0 International</dc:rights>
<dc:creator>Amelio, Ivano</dc:creator>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/59306"/>
<dc:contributor>Butera, Alessio</dc:contributor>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/59306/1/Caporali_2-oj6ztbi7b1w93.pdf"/>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-11-28T12:21:21Z</dc:date>
<dc:creator>Caporali, Sabrina</dc:creator>
<dcterms:title>BAP1 in cancer : epigenetic stability and genome integrity</dcterms:title>
<dcterms:abstract xml:lang="eng">Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display hypersusceptibility to exposure-associated cancers, such as asbestos-driven mesothelioma, thus BAP1 status has been postulated to participate in gene-environment interaction. Intriguingly, BAP1 functions display also a high degree of tissue dependency, associated to a peculiar cancer spectrum and cell types of specific functions. Mechanistically, BAP1 functions as an ubiquitin carboxy-terminal hydrolase (UCH) and controls regulatory ubiquitination of histones as well as degradative ubiquitination of a range of protein substrates. In this article we provide an overview of the most relevant findings on BAP1, underpinning its tissue specific tumour suppressor function. We also discuss the importance of its epigenetic role versus the control of protein stability in the regulation of genomic integrity.</dcterms:abstract>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dc:language>eng</dc:language>
<dcterms:issued>2022-11-01</dcterms:issued>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/59306/1/Caporali_2-oj6ztbi7b1w93.pdf"/>
<dc:creator>Butera, Alessio</dc:creator>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-11-28T12:21:21Z</dcterms:available>
<dc:contributor>Caporali, Sabrina</dc:contributor>
<dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
</rdf:Description>
</rdf:RDF>Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Unbekannt
