BAP1 in cancer : epigenetic stability and genome integrity

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2022
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Discover Oncology. Springer. 2022, 13(1), 117. eISSN 2730-6011. Available under: doi: 10.1007/s12672-022-00579-x
Zusammenfassung

Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display hypersusceptibility to exposure-associated cancers, such as asbestos-driven mesothelioma, thus BAP1 status has been postulated to participate in gene-environment interaction. Intriguingly, BAP1 functions display also a high degree of tissue dependency, associated to a peculiar cancer spectrum and cell types of specific functions. Mechanistically, BAP1 functions as an ubiquitin carboxy-terminal hydrolase (UCH) and controls regulatory ubiquitination of histones as well as degradative ubiquitination of a range of protein substrates. In this article we provide an overview of the most relevant findings on BAP1, underpinning its tissue specific tumour suppressor function. We also discuss the importance of its epigenetic role versus the control of protein stability in the regulation of genomic integrity.

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570 Biowissenschaften, Biologie
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ISO 690CAPORALI, Sabrina, Alessio BUTERA, Ivano AMELIO, 2022. BAP1 in cancer : epigenetic stability and genome integrity. In: Discover Oncology. Springer. 2022, 13(1), 117. eISSN 2730-6011. Available under: doi: 10.1007/s12672-022-00579-x
BibTex
@article{Caporali2022-11-01cance-59306,
  year={2022},
  doi={10.1007/s12672-022-00579-x},
  title={BAP1 in cancer : epigenetic stability and genome integrity},
  number={1},
  volume={13},
  journal={Discover Oncology},
  author={Caporali, Sabrina and Butera, Alessio and Amelio, Ivano},
  note={Article Number: 117}
}
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