chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche

Tseng, Chen-Yuan; Burel, Michael; Cammer, Michael; Harsh, Sneh; Flaherty, Maria Sol; Baumgartner, Stefan; Bach, Erika A.

chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche

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Date

2022

Authors

Tseng, Chen-Yuan

Burel, Michael

Cammer, Michael

Harsh, Sneh

Flaherty, Maria Sol

Baumgartner, Stefan

Bach, Erika A.

DOI (citable link)

10.1016/j.devcel.2021.12.004

Collections

Biologie

Publication type

Journal article

Publication status

Published

Published in

Developmental Cell ; 57 (2022), 1. - pp. 80-94.e7. - Cell Press. - ISSN 1534-5807. - eISSN 1878-1551

Abstract

Niches maintain a finite pool of stem cells via restricted space and short-range signals. Stem cells compete for limited niche resources, but the mechanisms regulating competition are poorly understood. Using the Drosophila testis model, we show that germline stem cells (GSCs) lacking the transcription factor Chinmo gain a competitive advantage for niche access. Surprisingly, chinmo^−/− GSCs rely on a new mechanism of competition in which they secrete the extracellular matrix protein Perlecan to selectively evict non-mutant GSCs and then upregulate Perlecan-binding proteins to remain in the altered niche. Over time, the GSC pool can be entirely replaced with chinmo^−/− cells. As a consequence, the mutant chinmo allele acts as a gene drive element; the majority of offspring inherit the allele despite the heterozygous genotype of the parent. Our results suggest that the influence of GSC competition may extend beyond individual stem cell niche dynamics to population-level allelic drift and evolution.

Subject (DDC)

570 Biosciences, Biology

Cite This

ISO 690

TSENG, Chen-Yuan, Michael BUREL, Michael CAMMER, Sneh HARSH, Maria Sol FLAHERTY, Stefan BAUMGARTNER, Erika A. BACH, 2022. chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche. In: Developmental Cell. Cell Press. 57(1), pp. 80-94.e7. ISSN 1534-5807. eISSN 1878-1551. Available under: doi: 10.1016/j.devcel.2021.12.004

BibTex

@article{Tseng2022chinm-56455,
  year={2022},
  doi={10.1016/j.devcel.2021.12.004},
  title={chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche},
  number={1},
  volume={57},
  issn={1534-5807},
  journal={Developmental Cell},
  pages={80--94.e7},
  author={Tseng, Chen-Yuan and Burel, Michael and Cammer, Michael and Harsh, Sneh and Flaherty, Maria Sol and Baumgartner, Stefan and Bach, Erika A.}
}

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Refereed

Yes