Lung epithelial apoptosis in influenza virus pneumonia : the role of macrophage-expressed TNF-related apoptosis-inducing ligand

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2008
Autor:innen
Herold, Susanne
Steinmueller, Mirko
von Wulffen, Werner
Cakarova, Lidija
Pinto, Ruth
Pleschka, Stephan
Kuziel, William A.
Corazza, Nadia
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Journal of Experimental Medicine. 2008, 205(13), pp. 3065-3077. ISSN 0022-1007. eISSN 1540-9538. Available under: doi: 10.1084/jem.20080201
Zusammenfassung

Mononuclear phagocytes have been attributed a crucial role in the host defense toward influenza virus (IV), but their contribution to influenza-induced lung failure is incompletely understood. We demonstrate for the first time that lung-recruited “exudate” macrophages significantly contribute to alveolar epithelial cell (AEC) apoptosis by the release of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in a murine model of influenza-induced pneumonia. Using CC-chemokine receptor 2–deficient (CCR2−/−) mice characterized by defective inflammatory macrophage recruitment, and blocking anti-CCR2 antibodies, we show that exudate macrophage accumulation in the lungs of influenza-infected mice is associated with pronounced AEC apoptosis and increased lung leakage and mortality. Among several proapoptotic mediators analyzed, TRAIL messenger RNA was found to be markedly up-regulated in alveolar exudate macrophages as compared with peripheral blood monocytes. Moreover, among the different alveolar-recruited leukocyte subsets, TRAIL protein was predominantly expressed on macrophages. Finally, abrogation of TRAIL signaling in exudate macrophages resulted in significantly reduced AEC apoptosis, attenuated lung leakage, and increased survival upon IV infection. Collectively, these findings demonstrate a key role for exudate macrophages in the induction of alveolar leakage and mortality in IV pneumonia. Epithelial cell apoptosis induced by TRAIL-expressing macrophages is identified as a major underlying mechanism.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690HEROLD, Susanne, Mirko STEINMUELLER, Werner VON WULFFEN, Lidija CAKAROVA, Ruth PINTO, Stephan PLESCHKA, Matthias MACK, William A. KUZIEL, Nadia CORAZZA, Thomas BRUNNER, Werner SEEGER, Juergen LOHMEYER, 2008. Lung epithelial apoptosis in influenza virus pneumonia : the role of macrophage-expressed TNF-related apoptosis-inducing ligand. In: Journal of Experimental Medicine. 2008, 205(13), pp. 3065-3077. ISSN 0022-1007. eISSN 1540-9538. Available under: doi: 10.1084/jem.20080201
BibTex
@article{Herold2008-12-22epith-14261,
  year={2008},
  doi={10.1084/jem.20080201},
  title={Lung epithelial apoptosis in influenza virus pneumonia : the role of macrophage-expressed TNF-related apoptosis-inducing ligand},
  number={13},
  volume={205},
  issn={0022-1007},
  journal={Journal of Experimental Medicine},
  pages={3065--3077},
  author={Herold, Susanne and Steinmueller, Mirko and von Wulffen, Werner and Cakarova, Lidija and Pinto, Ruth and Pleschka, Stephan and Mack, Matthias and Kuziel, William A. and Corazza, Nadia and Brunner, Thomas and Seeger, Werner and Lohmeyer, Juergen}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/14261">
    <dcterms:abstract xml:lang="eng">Mononuclear phagocytes have been attributed a crucial role in the host defense toward influenza virus (IV), but their contribution to influenza-induced lung failure is incompletely understood. We demonstrate for the first time that lung-recruited “exudate” macrophages significantly contribute to alveolar epithelial cell (AEC) apoptosis by the release of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in a murine model of influenza-induced pneumonia. Using CC-chemokine receptor 2–deficient (CCR2−/−) mice characterized by defective inflammatory macrophage recruitment, and blocking anti-CCR2 antibodies, we show that exudate macrophage accumulation in the lungs of influenza-infected mice is associated with pronounced AEC apoptosis and increased lung leakage and mortality. Among several proapoptotic mediators analyzed, TRAIL messenger RNA was found to be markedly up-regulated in alveolar exudate macrophages as compared with peripheral blood monocytes. Moreover, among the different alveolar-recruited leukocyte subsets, TRAIL protein was predominantly expressed on macrophages. Finally, abrogation of TRAIL signaling in exudate macrophages resulted in significantly reduced AEC apoptosis, attenuated lung leakage, and increased survival upon IV infection. Collectively, these findings demonstrate a key role for exudate macrophages in the induction of alveolar leakage and mortality in IV pneumonia. Epithelial cell apoptosis induced by TRAIL-expressing macrophages is identified as a major underlying mechanism.</dcterms:abstract>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:language>eng</dc:language>
    <dc:contributor>Lohmeyer, Juergen</dc:contributor>
    <dc:contributor>Seeger, Werner</dc:contributor>
    <dc:contributor>Mack, Matthias</dc:contributor>
    <dc:creator>Brunner, Thomas</dc:creator>
    <dc:creator>Pinto, Ruth</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14261"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14261/2/2008_Herold_JEM_1208.pdf"/>
    <dc:creator>Seeger, Werner</dc:creator>
    <dc:contributor>Cakarova, Lidija</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-02T07:56:00Z</dcterms:available>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Steinmueller, Mirko</dc:creator>
    <dc:contributor>Kuziel, William A.</dc:contributor>
    <dc:creator>Kuziel, William A.</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14261/2/2008_Herold_JEM_1208.pdf"/>
    <dc:rights>terms-of-use</dc:rights>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Pleschka, Stephan</dc:contributor>
    <dc:contributor>von Wulffen, Werner</dc:contributor>
    <dc:contributor>Pinto, Ruth</dc:contributor>
    <dc:contributor>Corazza, Nadia</dc:contributor>
    <dcterms:issued>2008-12-22</dcterms:issued>
    <dc:creator>Mack, Matthias</dc:creator>
    <dc:creator>Herold, Susanne</dc:creator>
    <dc:creator>Corazza, Nadia</dc:creator>
    <dc:creator>Pleschka, Stephan</dc:creator>
    <dc:contributor>Herold, Susanne</dc:contributor>
    <dc:creator>von Wulffen, Werner</dc:creator>
    <dcterms:title>Lung epithelial apoptosis in influenza virus pneumonia : the role of macrophage-expressed TNF-related apoptosis-inducing ligand</dcterms:title>
    <dc:creator>Cakarova, Lidija</dc:creator>
    <dc:contributor>Steinmueller, Mirko</dc:contributor>
    <dc:creator>Lohmeyer, Juergen</dc:creator>
    <dc:contributor>Brunner, Thomas</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-02T07:56:00Z</dc:date>
    <dcterms:bibliographicCitation>First publ. in: Journal of Experimental Medicine ; 205 (2008), 13. - pp. 3065-3077</dcterms:bibliographicCitation>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen