Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration

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2000
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Klingbeil, Candice K.
Schlaepfer, David D.
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Immunologic Research. 2000, 21(2/3), pp. 293-303. ISSN 1931-857X. eISSN 0257-277X. Available under: doi: 10.1385/IR:21:2-3:293
Zusammenfassung

In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix components, and cells of solid organs are critical control points of the overall immune response. Both the soluble chemokine and cell adhesion receptor-mediated migration signals must converge on common intracellular targets to engage the cell migration machinery. In this article, we focus on the role of focal adhesion kinase (FAK) and its homolog Pyk2 as cytoplasmic mediators of motility events in multiple cell types. We introduce the overall domain structure of the FAK and Pyk2 nonreceptor protein tyrosine kinases (prKs), highlight some of the signals that activate these prKs, and detail the molecules that functionally interact and signal transduction pathwayst hat may mediate cell migration responses. Emphasis is placed on the knowledge gained from studies using FAK-null cells as a model system to decipher the role of this PTK in promoting cell motility.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Cell migration, Focal Adhesion Kinase, Chemokine receptors, Integrin receptors, Src family kinases
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Zitieren
ISO 690HAUCK, Christof R., Candice K. KLINGBEIL, David D. SCHLAEPFER, 2000. Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration. In: Immunologic Research. 2000, 21(2/3), pp. 293-303. ISSN 1931-857X. eISSN 0257-277X. Available under: doi: 10.1385/IR:21:2-3:293
BibTex
@article{Hauck2000Focal-8526,
  year={2000},
  doi={10.1385/IR:21:2-3:293},
  title={Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration},
  number={2/3},
  volume={21},
  issn={1931-857X},
  journal={Immunologic Research},
  pages={293--303},
  author={Hauck, Christof R. and Klingbeil, Candice K. and Schlaepfer, David D.}
}
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