Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration

Lade...
Vorschaubild
Datum
2000
Autor:innen
Klingbeil, Candice K.
Schlaepfer, David D.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Immunologic Research. 2000, 21(2/3), pp. 293-303. ISSN 1931-857X. eISSN 0257-277X. Available under: doi: 10.1385/IR:21:2-3:293
Zusammenfassung

In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix components, and cells of solid organs are critical control points of the overall immune response. Both the soluble chemokine and cell adhesion receptor-mediated migration signals must converge on common intracellular targets to engage the cell migration machinery. In this article, we focus on the role of focal adhesion kinase (FAK) and its homolog Pyk2 as cytoplasmic mediators of motility events in multiple cell types. We introduce the overall domain structure of the FAK and Pyk2 nonreceptor protein tyrosine kinases (prKs), highlight some of the signals that activate these prKs, and detail the molecules that functionally interact and signal transduction pathwayst hat may mediate cell migration responses. Emphasis is placed on the knowledge gained from studies using FAK-null cells as a model system to decipher the role of this PTK in promoting cell motility.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Cell migration, Focal Adhesion Kinase, Chemokine receptors, Integrin receptors, Src family kinases
Konferenz
Rezension
undefined / . - undefined, undefined
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Datensätze
Zitieren
ISO 690HAUCK, Christof R., Candice K. KLINGBEIL, David D. SCHLAEPFER, 2000. Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration. In: Immunologic Research. 2000, 21(2/3), pp. 293-303. ISSN 1931-857X. eISSN 0257-277X. Available under: doi: 10.1385/IR:21:2-3:293
BibTex
@article{Hauck2000Focal-8526,
  year={2000},
  doi={10.1385/IR:21:2-3:293},
  title={Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration},
  number={2/3},
  volume={21},
  issn={1931-857X},
  journal={Immunologic Research},
  pages={293--303},
  author={Hauck, Christof R. and Klingbeil, Candice K. and Schlaepfer, David D.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/8526">
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8526/1/Focal_adhesion_kinase_functions_as_a_receptor_proximal_signaling_component_required_for_directed_cell_migration.pdf"/>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
    <dc:contributor>Hauck, Christof R.</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:24Z</dcterms:available>
    <dc:language>eng</dc:language>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:bibliographicCitation>First publ. in: Immunologic Research 21 (2000), 2/3, pp. 293-303</dcterms:bibliographicCitation>
    <dc:creator>Hauck, Christof R.</dc:creator>
    <dc:format>application/pdf</dc:format>
    <dc:creator>Klingbeil, Candice K.</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:title>Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration</dcterms:title>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8526/1/Focal_adhesion_kinase_functions_as_a_receptor_proximal_signaling_component_required_for_directed_cell_migration.pdf"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:24Z</dc:date>
    <dc:contributor>Klingbeil, Candice K.</dc:contributor>
    <dcterms:issued>2000</dcterms:issued>
    <dc:creator>Schlaepfer, David D.</dc:creator>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8526"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
    <dcterms:abstract xml:lang="eng">In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix components, and cells of solid organs are critical control points of the overall immune response. Both the soluble chemokine and cell adhesion receptor-mediated migration signals must converge on common intracellular targets to engage the cell migration machinery. In this article, we focus on the role of focal adhesion kinase (FAK) and its homolog Pyk2 as cytoplasmic mediators of motility events in multiple cell types. We introduce the overall domain structure of the FAK and Pyk2 nonreceptor protein tyrosine kinases (prKs), highlight some of the signals that activate these prKs, and detail the molecules that functionally interact and signal transduction pathwayst hat may mediate cell migration responses. Emphasis is placed on the knowledge gained from studies using FAK-null cells as a model system to decipher the role of this PTK in promoting cell motility.</dcterms:abstract>
    <dc:contributor>Schlaepfer, David D.</dc:contributor>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen