From Caspases to Alternative Cell-Death Mechanisms

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2003
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Jäättelä, Marja
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YIN, Xiao-Ming, ed., Zheng DONG, ed.. Essentials of apoptosis : a guide for basic and clinical research. Totowa, NJ: Humana Press, 2003, pp. 101-122. ISBN 978-1-4757-5172-7. Available under: doi: 10.1007/978-1-59259-361-3_7
Zusammenfassung

Programmed cell death (PCD) is essential for the development and maintenance of multicellular organisms. Many eukaryotic cells that die and are removed in a programmed way undergo an astonishingly stereotypical series of biochemical and morphological changes, the most defining features of which are the activation of caspases, chromatin condensation, and the display of phagocytosis markers on the cell surface (1–4). The underlying death process has been called apoptosis to delineate it clearly from other death programs. A single family of proteases, the caspases, has been considered the pivotal executioner of all programmed cell death. However, recent findings of evolutionary-conserved, caspase-independent, controlled-death mechanisms have opened new perspectives on the biology of cell demise, with implications in particular for neurobiology, cancer research, and immunological processes (4–7).

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570 Biowissenschaften, Biologie
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ISO 690JÄÄTTELÄ, Marja, Marcel LEIST, 2003. From Caspases to Alternative Cell-Death Mechanisms. In: YIN, Xiao-Ming, ed., Zheng DONG, ed.. Essentials of apoptosis : a guide for basic and clinical research. Totowa, NJ: Humana Press, 2003, pp. 101-122. ISBN 978-1-4757-5172-7. Available under: doi: 10.1007/978-1-59259-361-3_7
BibTex
@incollection{Jaattela2003Caspa-40515,
  year={2003},
  doi={10.1007/978-1-59259-361-3_7},
  title={From Caspases to Alternative Cell-Death Mechanisms},
  isbn={978-1-4757-5172-7},
  publisher={Humana Press},
  address={Totowa, NJ},
  booktitle={Essentials of apoptosis : a guide for basic and clinical research},
  pages={101--122},
  editor={Yin, Xiao-Ming and Dong, Zheng},
  author={Jäättelä, Marja and Leist, Marcel}
}
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