Publikation: Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors
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Objectives: Protein tyrosine phosphatases are key regulators of intracellular signaling that contribute to determining cancer cell growth, which thus makes them attractive targets for therapeutic and diagnostic agents. SHP-1 phosphotyrosine phosphatase is rarely expressed in epithelial tumor cells, but expression has been found in several breast cancer cell lines and tumors. To determine the potential significance of SHP-1 as a prognostic marker in the clinical setting, we examined SHP-1 protein expression in breast tumors. Methods: We analyzed SHP-1 expression by immunohistochemistry in a breast tissue microarray composed of 2,081 cores, either alone or in combination with known prognostic markers. Results: Our data showed that SHP-1 expression was confined to a well-defined subset of high-grade tumors characterized by unique biological parameters. SHP-1 expression correlated directly with expression of the tyrosine kinase receptor HER-2 and inversely with expression of the estrogen receptor, while it was weakly associated with Bcl-2 expression. Conclusions: Levels of SHP-1 were correlated with conventional pathologic parameters of tumor aggressiveness and were associated with reduced patient survival, suggesting that elevated expression of SHP-1 is a common molecular abnormality in a defined subset of breast tumors and might be used in routine diagnosis to identify patients with high-risk tumors.
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INSABATO, Luigi, Ivano AMELIO, Maria QUARTO, Antonella ZANNETTI, Fabio TOLINO, Gaia DE MAURO, Laura CERCHIA, Patrizia RICCIO, Daniel BAUMHOER, Gerolama CONDORELLI, 2009. Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors. In: Oncology. Karger. 2009, 77(6), pp. 378-384. ISSN 0030-2414. eISSN 1423-0232. Available under: doi: 10.1159/000276765BibTex
@article{Insabato2009Eleva-57135, year={2009}, doi={10.1159/000276765}, title={Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors}, number={6}, volume={77}, issn={0030-2414}, journal={Oncology}, pages={378--384}, author={Insabato, Luigi and Amelio, Ivano and Quarto, Maria and Zannetti, Antonella and Tolino, Fabio and de Mauro, Gaia and Cerchia, Laura and Riccio, Patrizia and Baumhoer, Daniel and Condorelli, Gerolama} }
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