Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors

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2009
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Insabato, Luigi
Quarto, Maria
Zannetti, Antonella
Tolino, Fabio
de Mauro, Gaia
Cerchia, Laura
Riccio, Patrizia
Baumhoer, Daniel
Condorelli, Gerolama
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Oncology. Karger. 2009, 77(6), pp. 378-384. ISSN 0030-2414. eISSN 1423-0232. Available under: doi: 10.1159/000276765
Zusammenfassung

Objectives: Protein tyrosine phosphatases are key regulators of intracellular signaling that contribute to determining cancer cell growth, which thus makes them attractive targets for therapeutic and diagnostic agents. SHP-1 phosphotyrosine phosphatase is rarely expressed in epithelial tumor cells, but expression has been found in several breast cancer cell lines and tumors. To determine the potential significance of SHP-1 as a prognostic marker in the clinical setting, we examined SHP-1 protein expression in breast tumors. Methods: We analyzed SHP-1 expression by immunohistochemistry in a breast tissue microarray composed of 2,081 cores, either alone or in combination with known prognostic markers. Results: Our data showed that SHP-1 expression was confined to a well-defined subset of high-grade tumors characterized by unique biological parameters. SHP-1 expression correlated directly with expression of the tyrosine kinase receptor HER-2 and inversely with expression of the estrogen receptor, while it was weakly associated with Bcl-2 expression. Conclusions: Levels of SHP-1 were correlated with conventional pathologic parameters of tumor aggressiveness and were associated with reduced patient survival, suggesting that elevated expression of SHP-1 is a common molecular abnormality in a defined subset of breast tumors and might be used in routine diagnosis to identify patients with high-risk tumors.

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570 Biowissenschaften, Biologie
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Breast cancer, Tissue microarray, Tyrosine phosphatase, Clinical setting, SHP-1
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ISO 690INSABATO, Luigi, Ivano AMELIO, Maria QUARTO, Antonella ZANNETTI, Fabio TOLINO, Gaia DE MAURO, Laura CERCHIA, Patrizia RICCIO, Daniel BAUMHOER, Gerolama CONDORELLI, 2009. Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors. In: Oncology. Karger. 2009, 77(6), pp. 378-384. ISSN 0030-2414. eISSN 1423-0232. Available under: doi: 10.1159/000276765
BibTex
@article{Insabato2009Eleva-57135,
  year={2009},
  doi={10.1159/000276765},
  title={Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors},
  number={6},
  volume={77},
  issn={0030-2414},
  journal={Oncology},
  pages={378--384},
  author={Insabato, Luigi and Amelio, Ivano and Quarto, Maria and Zannetti, Antonella and Tolino, Fabio and de Mauro, Gaia and Cerchia, Laura and Riccio, Patrizia and Baumhoer, Daniel and Condorelli, Gerolama}
}
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