@article{Borisova2013Integ-21823,
  year={2013},
  doi={10.1186/1471-2121-14-2},
  title={Integrin-mediated internalization of Staphylococcus aureus does not require vinculin},
  number={1},
  volume={14},
  issn={1471-2121},
  journal={BMC Cell Biology},
  author={Borisova, Marina and Shi, Yong and Buntru, Alexander and Wörner, Susanne and Ziegler, Wolfgang H. and Hauck, Christof R.},
  note={Article Number: 2}
}

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    <dc:creator>Wörner, Susanne</dc:creator>
    <dc:creator>Buntru, Alexander</dc:creator>
    <dc:creator>Ziegler, Wolfgang H.</dc:creator>
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    <dc:contributor>Buntru, Alexander</dc:contributor>
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    <dc:contributor>Shi, Yong</dc:contributor>
    <dc:creator>Hauck, Christof R.</dc:creator>
    <dc:contributor>Ziegler, Wolfgang H.</dc:contributor>
    <dc:contributor>Hauck, Christof R.</dc:contributor>
    <dc:creator>Shi, Yong</dc:creator>
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    <dc:contributor>Wörner, Susanne</dc:contributor>
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    <dcterms:bibliographicCitation>BMC Cell Biology ; 14 (2013). - 2</dcterms:bibliographicCitation>
    <dc:creator>Borisova, Marina</dc:creator>
    <dcterms:title>Integrin-mediated internalization of Staphylococcus aureus does not require vinculin</dcterms:title>
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    <dcterms:abstract xml:lang="eng">Background: Disease manifestations of Staphylococcus aureus are connected to the fibronectin (Fn)-binding&lt;br /&gt;capacity of these Gram-positive pathogens. Fn deposition on the surface of S. aureus allows engagement of α5β1 integrins and triggers uptake by host cells. For several integrin- and actin-associated cytoplasmic proteins, including FAK, Src, N-WASP, tensin and cortactin, a functional role during bacterial invasion has been demonstrated. As&lt;br /&gt;reorganization of the actin cytoskeleton is critical for bacterial entry, we investigated whether vinculin, an essential protein linking integrins with the actin cytoskeleton, may contribute to the integrin-mediated internalization of S. aureus.&lt;br /&gt;Results: Complementation of vinculin in vinculin -/- cells, vinculin overexpression, as well as shRNA-mediated vinculin knock-down in different eukaryotic cell types demonstrate, that vinculin does not have a functional role during the integrin-mediated uptake of S. aureus.&lt;br /&gt;Conclusions: Our results suggest that vinculin is insignificant for the integrin-mediated uptake of S. aureus despite the critical role of vinculin as a linker between integrins and F-actin.</dcterms:abstract>
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    <dc:contributor>Borisova, Marina</dc:contributor>
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