Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation

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2010
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Zimmermann, Wolfgang
Hentschel, Jochen
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Science. 2010, 329(5996), pp. 1197-1201. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1190892
Zusammenfassung

Colonization of mucosal surfaces is the key initial step in most bacterial infections. One mechanism protecting the mucosa is the rapid shedding of epithelial cells, also termed exfoliation, but it is unclear how pathogens counteract this process. We found that carcinoembryonic antigen (CEA)–binding bacteria colonized the urogenital tract of CEA transgenic mice, but not of wild-type mice, by suppressing exfoliation of mucosal cells. CEA binding triggered de novo expression of the transforming growth factor receptor CD105, changing focal adhesion composition and activating β1 integrins. This manipulation of integrin inside-out signaling promotes efficient mucosal colonization and represents a potential target to prevent or cure bacterial infections.

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570 Biowissenschaften, Biologie
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ISO 690MÜNZNER, Petra, Verena BACHMANN, Wolfgang ZIMMERMANN, Jochen HENTSCHEL, Christof R. HAUCK, 2010. Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation. In: Science. 2010, 329(5996), pp. 1197-1201. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1190892
BibTex
@article{Munzner2010Human-12574,
  year={2010},
  doi={10.1126/science.1190892},
  title={Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation},
  number={5996},
  volume={329},
  issn={0036-8075},
  journal={Science},
  pages={1197--1201},
  author={Münzner, Petra and Bachmann, Verena and Zimmermann, Wolfgang and Hentschel, Jochen and Hauck, Christof R.}
}
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