Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation

Münzner, Petra; Bachmann, Verena; Zimmermann, Wolfgang; Hentschel, Jochen; Hauck, Christof R.

Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation

Dateien

Muenzner_Science_329_b.pdfGröße: 2.45 MBDownloads: 597

Datum

2010

Autor:innen

Münzner, Petra

Bachmann, Verena

Zimmermann, Wolfgang

Hentschel, Jochen

Hauck, Christof R.

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Science. 2010, 329(5996), pp. 1197-1201. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1190892

Zusammenfassung

Colonization of mucosal surfaces is the key initial step in most bacterial infections. One mechanism protecting the mucosa is the rapid shedding of epithelial cells, also termed exfoliation, but it is unclear how pathogens counteract this process. We found that carcinoembryonic antigen (CEA)–binding bacteria colonized the urogenital tract of CEA transgenic mice, but not of wild-type mice, by suppressing exfoliation of mucosal cells. CEA binding triggered de novo expression of the transforming growth factor receptor CD105, changing focal adhesion composition and activating β1 integrins. This manipulation of integrin inside-out signaling promotes efficient mucosal colonization and represents a potential target to prevent or cure bacterial infections.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

MÜNZNER, Petra, Verena BACHMANN, Wolfgang ZIMMERMANN, Jochen HENTSCHEL, Christof R. HAUCK, 2010. Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation. In: Science. 2010, 329(5996), pp. 1197-1201. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1190892

BibTex

@article{Munzner2010Human-12574,
  year={2010},
  doi={10.1126/science.1190892},
  title={Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation},
  number={5996},
  volume={329},
  issn={0036-8075},
  journal={Science},
  pages={1197--1201},
  author={Münzner, Petra and Bachmann, Verena and Zimmermann, Wolfgang and Hentschel, Jochen and Hauck, Christof R.}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/12574">
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/12574"/>
    <dc:creator>Hentschel, Jochen</dc:creator>
    <dc:contributor>Münzner, Petra</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:bibliographicCitation>First publ. in: Science 329 (2010), 5996, pp. 1197-1201</dcterms:bibliographicCitation>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:issued>2010</dcterms:issued>
    <dc:contributor>Hauck, Christof R.</dc:contributor>
    <dcterms:abstract xml:lang="eng">Colonization of mucosal surfaces is the key initial step in most bacterial infections. One mechanism protecting the mucosa is the rapid shedding of epithelial cells, also termed exfoliation, but it is unclear how pathogens counteract this process. We found that carcinoembryonic antigen (CEA)–binding bacteria colonized the urogenital tract of CEA transgenic mice, but not of wild-type mice, by suppressing exfoliation of mucosal cells. CEA binding triggered de novo expression of the transforming growth factor receptor CD105, changing focal adhesion composition and activating β1 integrins. This manipulation of integrin inside-out signaling promotes efficient mucosal colonization and represents a potential target to prevent or cure bacterial infections.</dcterms:abstract>
    <dc:creator>Bachmann, Verena</dc:creator>
    <dc:creator>Hauck, Christof R.</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-21T09:12:26Z</dc:date>
    <dc:contributor>Zimmermann, Wolfgang</dc:contributor>
    <dc:contributor>Hentschel, Jochen</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-21T09:12:26Z</dcterms:available>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/12574/1/Muenzner_Science_329_b.pdf"/>
    <dc:language>eng</dc:language>
    <dcterms:title>Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation</dcterms:title>
    <dc:creator>Zimmermann, Wolfgang</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/12574/1/Muenzner_Science_329_b.pdf"/>
    <dc:contributor>Bachmann, Verena</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Münzner, Petra</dc:creator>
  </rdf:Description>
</rdf:RDF>

Universitätsbibliographie

Ja