Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers

Lade...
Vorschaubild
Dateien
Booji_0-400933.pdf
Booji_0-400933.pdfGröße: 960.51 KBDownloads: 221
Datum
2016
Autor:innen
Booij, Linda
Welfeld, Krzysztof
Leyton, Marco
Dagher, Alain
Boileau, Isabelle
Sibon, Igor
Baker, Glen B.
Diksic, Mirko
Benkelfat, Chawki
et al.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Link zur Lizenz
EU-Projektnummer
DFG-Projektnummer
Projekt
Open Access-Veröffentlichung
Sammlungen
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Translational Psychiatry. 2016, 6(2), e740. eISSN 2158-3188. Available under: doi: 10.1038/tp.2016.6
Zusammenfassung

Dysregulation of the stress response system is a potential etiological factor in the development of and relapse to multiple neuropsychiatric disorders. Previously we reported that repeated intermittent d-amphetamine administration can lead to progressively greater dopamine release, thereby providing evidence of drug-induced neurochemical sensitization. Here, we test the hypothesis that repeated exposure to d-amphetamine increases dopaminergic responses to stress; that is, produces cross-sensitization. Using positron emission tomography, we measured in 17 healthy male volunteers (mean ± s.d. = 22.1 ± 3.4 years) [(11)C]raclopride binding responses to a validated psychosocial stress task before and 2 weeks after a regimen of repeated d-amphetamine (3 × 0.3 mg kg(-1), by mouth; n = 8) or placebo (3 × lactose, by mouth; n = 9). Mood and physiological measurements were recorded throughout each session. Before the d-amphetamine regimen, exposure to the stress task increased behavioral and physiological indices of stress (anxiety, heart rate, cortisol, all P ⩽ 0.05). Following the d-amphetamine regimen, the stress-induced cortisol responses were augmented (P < 0.04), and voxel-based analyses showed larger stress-induced decreases in [(11)C]raclopride non-displaceable binding potential across the striatum. In the placebo group, re-exposure to stress led to smaller clusters of decreased [(11)C]raclopride binding, primarily in the sensorimotor striatum (P < 0.05). Together, this study provides evidence for drug × stress cross-sensitization; moreover, random exposure to stimulants and/or stress cumulatively, while enhancing dopamine release in striatal areas, may contribute to a lowered set point for psychopathologies in which altered dopamine neurotransmission is invoked.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690BOOIJ, Linda, Krzysztof WELFELD, Marco LEYTON, Alain DAGHER, Isabelle BOILEAU, Igor SIBON, Glen B. BAKER, Mirko DIKSIC, Jens C. PRUESSNER, Chawki BENKELFAT, 2016. Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers. In: Translational Psychiatry. 2016, 6(2), e740. eISSN 2158-3188. Available under: doi: 10.1038/tp.2016.6
BibTex
@article{Booij2016Dopam-38207,
  year={2016},
  doi={10.1038/tp.2016.6},
  title={Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers},
  number={2},
  volume={6},
  journal={Translational Psychiatry},
  author={Booij, Linda and Welfeld, Krzysztof and Leyton, Marco and Dagher, Alain and Boileau, Isabelle and Sibon, Igor and Baker, Glen B. and Diksic, Mirko and Pruessner, Jens C. and Benkelfat, Chawki},
  note={Article Number: e740}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/38207">
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/38207/3/Booji_0-400933.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:creator>Leyton, Marco</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-03-30T07:44:33Z</dcterms:available>
    <dc:language>eng</dc:language>
    <dc:contributor>Booij, Linda</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/38207/3/Booji_0-400933.pdf"/>
    <dc:contributor>Benkelfat, Chawki</dc:contributor>
    <dc:creator>Diksic, Mirko</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38207"/>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-03-30T07:44:33Z</dc:date>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Boileau, Isabelle</dc:creator>
    <dc:contributor>Sibon, Igor</dc:contributor>
    <dc:creator>Benkelfat, Chawki</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Dagher, Alain</dc:contributor>
    <dc:contributor>Leyton, Marco</dc:contributor>
    <dc:contributor>Diksic, Mirko</dc:contributor>
    <dc:contributor>Welfeld, Krzysztof</dc:contributor>
    <dc:creator>Booij, Linda</dc:creator>
    <dc:creator>Baker, Glen B.</dc:creator>
    <dc:creator>Dagher, Alain</dc:creator>
    <dcterms:title>Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers</dcterms:title>
    <dc:contributor>Boileau, Isabelle</dc:contributor>
    <dcterms:abstract xml:lang="eng">Dysregulation of the stress response system is a potential etiological factor in the development of and relapse to multiple neuropsychiatric disorders. Previously we reported that repeated intermittent d-amphetamine administration can lead to progressively greater dopamine release, thereby providing evidence of drug-induced neurochemical sensitization. Here, we test the hypothesis that repeated exposure to d-amphetamine increases dopaminergic responses to stress; that is, produces cross-sensitization. Using positron emission tomography, we measured in 17 healthy male volunteers (mean ± s.d. = 22.1 ± 3.4 years) [(11)C]raclopride binding responses to a validated psychosocial stress task before and 2 weeks after a regimen of repeated d-amphetamine (3 × 0.3 mg kg(-1), by mouth; n = 8) or placebo (3 × lactose, by mouth; n = 9). Mood and physiological measurements were recorded throughout each session. Before the d-amphetamine regimen, exposure to the stress task increased behavioral and physiological indices of stress (anxiety, heart rate, cortisol, all P ⩽ 0.05). Following the d-amphetamine regimen, the stress-induced cortisol responses were augmented (P &lt; 0.04), and voxel-based analyses showed larger stress-induced decreases in [(11)C]raclopride non-displaceable binding potential across the striatum. In the placebo group, re-exposure to stress led to smaller clusters of decreased [(11)C]raclopride binding, primarily in the sensorimotor striatum (P &lt; 0.05). Together, this study provides evidence for drug × stress cross-sensitization; moreover, random exposure to stimulants and/or stress cumulatively, while enhancing dopamine release in striatal areas, may contribute to a lowered set point for psychopathologies in which altered dopamine neurotransmission is invoked.</dcterms:abstract>
    <dcterms:issued>2016</dcterms:issued>
    <dc:creator>Sibon, Igor</dc:creator>
    <dc:contributor>Baker, Glen B.</dc:contributor>
    <dc:creator>Pruessner, Jens C.</dc:creator>
    <dc:creator>Welfeld, Krzysztof</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:contributor>Pruessner, Jens C.</dc:contributor>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet