Granulocyte Colony-Stimulating Factor (Filgrastim) Treatment Primes for Increased ex Vivo Inducible Prostanoid Release

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2004
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Boneberg, Eva-Maria
Diterich, Isabel
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Journal of Pharmacology and Experimental Therapeutics. 2004, 308(2), pp. 754-759
Zusammenfassung

We investigated whether anti-inflammatory effects of treatment with granulocyte colony-stimulating factor (G-CSF, filgrastim) are mediated via prostaglandin E2 (PGE2) induction. In a double-blind crossover study, 10 healthy volunteers received 300 μg of filgrastim or saline 1 week apart. This was repeated after oral administration of 50 mg of flurbiprofen 1 h before injection. The increase in neutrophilic granulocytes initiated by G-CSF was augmented significantly by flurbiprofen. Lipopolysaccharide- induced PGE2 and thromboxane (TxB2) release were increased 8 h after G-CSF treatment. This increase was abro-gated by flurbiprofen. However, flurbiprofen did not affect G-CSF-mediated decrease in tumor necrosis factor-α or interferon-γ release. Of the volunteers treated with G-CSF, eight reported side effects (headache and bone pain) against none in the saline group. When flurbiprofen was given before injection, one volunteer each reported side effects in the G-CSF and in the saline group. These data show that G-CSF primes for increased PGE2 and TxB2 release. Cyciooxygenase inhibition counteracts neither the hematopoietic nor the anti-inflammatory activity of G-CSF but reduces side effects.

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ISO 690AULOCK, Sonja von, Eva-Maria BONEBERG, Isabel DITERICH, Thomas HARTUNG, 2004. Granulocyte Colony-Stimulating Factor (Filgrastim) Treatment Primes for Increased ex Vivo Inducible Prostanoid Release. In: Journal of Pharmacology and Experimental Therapeutics. 2004, 308(2), pp. 754-759
BibTex
@article{Aulock2004Granu-6616,
  year={2004},
  title={Granulocyte Colony-Stimulating Factor (Filgrastim) Treatment Primes for Increased ex Vivo Inducible Prostanoid Release},
  number={2},
  volume={308},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={754--759},
  author={Aulock, Sonja von and Boneberg, Eva-Maria and Diterich, Isabel and Hartung, Thomas}
}
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