Publikation:

Patient-Specific Anisotropic Volume of Tissue Activated with the Lead-DBS Toolbox

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2021

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Amil, Alba Segura
Nowacki, Andreas
Pollo, Claudio
Khoa Nguyen, T. A.

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https://doi.org/10.1109/embc46164.2021.9629810
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Proceedings of the 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). Piscataway, NJ: IEEE, 2021, S. 6285-6288. ISSN 2375-7477. eISSN 2694-0604. ISBN 978-1-7281-1178-0. Verfügbar unter: doi: 10.1109/embc46164.2021.9629810

Zusammenfassung

Deep brain stimulation is an effective neurosurgical intervention for movement disorders such as Parkinson’s disease. Despite its success, the underlying mechanisms are still debated. One tool to better understand them is the Volume of Tissue Activated (VTA), that estimates the region activated by electrical stimulation. Different estimation approaches exist, these typically assume isotropic tissue properties and modelling of anisotropy is often lacking.The present work was aimed at developing and testing a method for patient-specific VTA estimation that incorporated an anisotropic conduction model. Our method was implemented within the open-source toolbox Lead-DBS and is accessible to the public.The present method was further tested with two patient cases and compared to a standard Lead-DBS pipeline for VTA estimation. This showed encouraging similarities in one test scenario and expected differences in another test scenario. Further validation with a wider cohort is warranted.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Satellite broadcasting, Pipelines, Estimation, Lead, Tools, Electrical stimulation, White matter

Konferenz

2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (Online), 1. Nov. 2021 - 5. Nov. 2021
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ISO 690GARZA, Roberto, Alba Segura AMIL, Andreas NOWACKI, Claudio POLLO, T. A. KHOA NGUYEN, 2021. Patient-Specific Anisotropic Volume of Tissue Activated with the Lead-DBS Toolbox. 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (Online), 1. Nov. 2021 - 5. Nov. 2021. In: Proceedings of the 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). Piscataway, NJ: IEEE, 2021, S. 6285-6288. ISSN 2375-7477. eISSN 2694-0604. ISBN 978-1-7281-1178-0. Verfügbar unter: doi: 10.1109/embc46164.2021.9629810
BibTex
@inproceedings{Garza2021-11-01Patie-75215,
  title={Patient-Specific Anisotropic Volume of Tissue Activated with the Lead-DBS Toolbox},
  year={2021},
  doi={10.1109/embc46164.2021.9629810},
  isbn={978-1-7281-1178-0},
  issn={2375-7477},
  address={Piscataway, NJ},
  publisher={IEEE},
  booktitle={Proceedings of the 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)},
  pages={6285--6288},
  author={Garza, Roberto and Amil, Alba Segura and Nowacki, Andreas and Pollo, Claudio and Khoa Nguyen, T. A.}
}
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