PrPc and reggies/flotillins are contained in and released via lipid-rich vesicles in Jurkat T cells

Kurzanzeige
dc.contributor.authorReuter, Alexander
dc.contributor.authorBinkle, Ulrike
dc.contributor.authorStürmer, Claudia
dc.contributor.authorPlattner, Helmut
dc.date.accessioned2011-03-24T17:31:10Zdeu
dc.date.available2011-03-24T17:31:10Zdeu
dc.date.issued2004deu
dc.description.abstractA new model of caveolin association with lipid body cores has recently been proposed which may be relevant to a number of cellular processes, e.g. lipid body generation. Here we show that PrPc and reggie-1 and reggie-2 also occur in the cores of Nile Red/Bodipy-stained (neutral lipid-containing) vesicular structures and, in immunoblots, in the lipid-enriched fraction after density gradient centrifugation. These lipid-rich vesicles increase in number following cell feeding with oleic acid, differ from early endosome antigen 1- and Lamp-2-positive endosomes/lysosomes, exhibit an opaque content and lack surrounding actin staining. Our results suggest that the content of these vesicles, together with reggie-1 and -2 and PrPc, is expelled.eng
dc.description.versionpublished
dc.format.mimetypeapplication/pdfdeu
dc.identifier.citationFirst publ. in: Cellular and Molecular Life Sciences 61 (2004), pp. 2092-2099deu
dc.identifier.doi10.1007/s00018-004-4193-x
dc.identifier.pmid15316658
dc.identifier.ppn273029347deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/7056
dc.language.isoengdeu
dc.legacy.dateIssued2007deu
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 Generic
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/
dc.subjectCellular prion proteindeu
dc.subjectreggie/flotillindeu
dc.subjectlipid-rich vesicledeu
dc.subjectrelease/exocytosisdeu
dc.subject.ddc570deu
dc.titlePrPc and reggies/flotillins are contained in and released via lipid-rich vesicles in Jurkat T cellseng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Reuter2004reggi-7056,
  year={2004},
  doi={10.1007/s00018-004-4193-x},
  title={PrPc and reggies/flotillins are contained in and released via lipid-rich vesicles in Jurkat T cells},
  number={16},
  volume={61},
  issn={1420-682X},
  journal={Cellular and Molecular Life Sciences},
  pages={2092--2099},
  author={Reuter, Alexander and Binkle, Ulrike and Stürmer, Claudia and Plattner, Helmut}
}
kops.citation.iso690REUTER, Alexander, Ulrike BINKLE, Claudia STÜRMER, Helmut PLATTNER, 2004. PrPc and reggies/flotillins are contained in and released via lipid-rich vesicles in Jurkat T cells. In: Cellular and Molecular Life Sciences. 2004, 61(16), pp. 2092-2099. ISSN 1420-682X. eISSN 1420-9071. Available under: doi: 10.1007/s00018-004-4193-xdeu
kops.citation.iso690REUTER, Alexander, Ulrike BINKLE, Claudia STÜRMER, Helmut PLATTNER, 2004. PrPc and reggies/flotillins are contained in and released via lipid-rich vesicles in Jurkat T cells. In: Cellular and Molecular Life Sciences. 2004, 61(16), pp. 2092-2099. ISSN 1420-682X. eISSN 1420-9071. Available under: doi: 10.1007/s00018-004-4193-xeng
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