Involvement of Hedgehog and FGF signalling in the lamprey telencephalon : evolution of regionalization and dorsoventral patterning of the vertebrate forebrain

Sugahara, Fumiaki; Aota, Shin-ichi; Kuraku, Shigehiro; Murakami, Yasunori; Takio-Ogawa, Yoko; Hirano, Shigeki; Kuratani, Shigeru

Involvement of Hedgehog and FGF signalling in the lamprey telencephalon : evolution of regionalization and dorsoventral patterning of the vertebrate forebrain

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Zu diesem Dokument gibt es keine Dateien.

Datum

2011

Autor:innen

Sugahara, Fumiaki

Aota, Shin-ichi

Kuraku, Shigehiro

Murakami, Yasunori

Takio-Ogawa, Yoko

Hirano, Shigeki

Kuratani, Shigeru

DOI (zitierfähiger Link)

https://doi.org/10.1242/dev.059360

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Development. Company of Biologists. 2011, 138(6), pp. 1217-1226. ISSN 0950-1991. eISSN 1477-9129. Available under: doi: 10.1242/dev.059360

Zusammenfassung

Dorsoventral (DV) specification is a crucial step for the development of the vertebrate telencephalon. Clarifying the origin of this mechanism will lead to a better understanding of vertebrate central nervous system (CNS) evolution. Based on the lamprey, a sister group of the gnathostomes (jawed vertebrates), we identified three lamprey Hedgehog (Hh) homologues, which are thought to play central signalling roles in telencephalon patterning. However, unlike in gnathostomes, none of these genes, nor Lhx6/7/8, a marker for the migrating interneuron subtype, was expressed in the ventral telencephalon, consistent with the reported absence of the medial ganglionic eminence (MGE) in this animal. Homologues of Gsh2, Isl1/2 and Sp8, which are involved in the patterning of the lateral ganglionic eminence (LGE) of gnathostomes, were expressed in the lamprey subpallium, as in gnathostomes. Hh signalling is necessary for induction of the subpallium identity in the gnathostome telencephalon. When Hh signalling was inhibited, the ventral identity was disrupted in the lamprey, suggesting that prechordal mesoderm-derived Hh signalling might be involved in the DV patterning of the telencephalon. By blocking fibroblast growth factor (FGF) signalling, the ventral telencephalon was suppressed in the lamprey, as in gnathostomes. We conclude that Hh- and FGF-dependent DV patterning, together with the resultant LGE identity, are likely to have been established in a common ancestor before the divergence of cyclostomes and gnathostomes. Later, gnathostomes would have acquired a novel Hh expression domain corresponding to the MGE, leading to the obtainment of cortical interneurons.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

SUGAHARA, Fumiaki, Shin-ichi AOTA, Shigehiro KURAKU, Yasunori MURAKAMI, Yoko TAKIO-OGAWA, Shigeki HIRANO, Shigeru KURATANI, 2011. Involvement of Hedgehog and FGF signalling in the lamprey telencephalon : evolution of regionalization and dorsoventral patterning of the vertebrate forebrain. In: Development. Company of Biologists. 2011, 138(6), pp. 1217-1226. ISSN 0950-1991. eISSN 1477-9129. Available under: doi: 10.1242/dev.059360

BibTex

@article{Sugahara2011-03Invol-51202,
  year={2011},
  doi={10.1242/dev.059360},
  title={Involvement of Hedgehog and FGF signalling in the lamprey telencephalon : evolution of regionalization and dorsoventral patterning of the vertebrate forebrain},
  number={6},
  volume={138},
  issn={0950-1991},
  journal={Development},
  pages={1217--1226},
  author={Sugahara, Fumiaki and Aota, Shin-ichi and Kuraku, Shigehiro and Murakami, Yasunori and Takio-Ogawa, Yoko and Hirano, Shigeki and Kuratani, Shigeru}
}

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