@article{Golden2019Nucle-51545,
  year={2019},
  doi={10.1523/JNEUROSCI.2409-18.2019},
  title={Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice},
  number={13},
  volume={39},
  issn={0270-6474},
  journal={The Journal of Neuroscience},
  pages={2482--2496},
  author={Golden, Sam A. and Jin, Michelle and Heins, Conor and Venniro, Marco and Michaelides, Michael and Shaham, Yavin}
}

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    <dc:contributor>Michaelides, Michael</dc:contributor>
    <dc:creator>Golden, Sam A.</dc:creator>
    <dc:creator>Venniro, Marco</dc:creator>
    <dc:contributor>Jin, Michelle</dc:contributor>
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    <dc:creator>Shaham, Yavin</dc:creator>
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    <dc:language>eng</dc:language>
    <dc:contributor>Heins, Conor</dc:contributor>
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    <dc:creator>Jin, Michelle</dc:creator>
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    <dc:contributor>Shaham, Yavin</dc:contributor>
    <dc:contributor>Venniro, Marco</dc:contributor>
    <dc:creator>Michaelides, Michael</dc:creator>
    <dcterms:title>Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice</dcterms:title>
    <dc:contributor>Golden, Sam A.</dc:contributor>
    <dc:creator>Heins, Conor</dc:creator>
    <dcterms:abstract xml:lang="eng">We recently developed a mouse model of appetitive operant aggression and reported that adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male mice and relapse to aggression seeking during abstinence. Here we studied the role of nucleus accumbens (NAc) dopamine receptor (Drd)1- and Drd2-expressing neurons in aggression self-administration and aggression seeking. We trained CD-1 mice to self-administer intruders (9 d, 12 trials/d) and tested them for aggression self-administration and aggression seeking on abstinence Day 1. We used immunohistochemistry and in situ hybridization to measure the neuronal activity marker Fos in the NAc, and cell-type-specific colocalization of Fos with Drd1- and Drd2-expressing neurons. To test the causal role of Drd1- and Drd2-expressing neurons, we validated a transgenic hybrid breeding strategy crossing inbred Drd1-Cre and Drd2-Cre transgenic mice with outbred CD-1 mice and used cell-type-specific Cre-DREADD (hM4Di) to inhibit NAc Drd1- and Drd2-expressing neuron activity. We found that aggression self-administration and aggression seeking induced higher Fos expression in NAc shell than in core, that Fos colocalized with Drd1 and Drd2 in both subregions, and that chemogenetic inhibition of Drd1-, but not Drd2-, expressing neurons decreased aggression self-administration and aggression seeking. Results indicate a cell-type-specific role of Drd1-expressing neurons that is critical for both aggression self-administration and aggression seeking. Our study also validates a simple breeding strategy between outbred CD-1 mice and inbred C57-based Cre lines that can be used to study cell-type and circuit mechanisms of aggression reward and relapse.</dcterms:abstract>
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