Total Synthesis of Parvineostemonine by Structure Pattern Recognition : A Unified Approach to Stemona and Sarpagine Alkaloids

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2018
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European Union (EU): 679418
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ANaPSyS - Artifical Natural Products System Synthesis
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Chemistry - A European Journal. 2018, 24(16), pp. 3994-3997. ISSN 0947-6539. eISSN 1521-3765. Available under: doi: 10.1002/chem.201800365
Zusammenfassung

Through structure pattern recognition based total synthesis we designed a synthesis in which two biogenetically unrelated natural product families (Stemona- and Sarpagine alkaloids) share 50 % of their synthetic sequence. In this report, the efficiency of such a strategic approach is demonstrated in the total synthesis of the Stemona alkaloid parvineostemonine, proceeding through a privileged intermediate that we have previously transformed into biogenetically completely unrelated Sarpagine alkaloids. In addition, we capitalized on the symmetry properties of the privileged intermediate, which was obtained as two regioisomers. After their separation by column chromatography the two regioisomers were converted to the corresponding pair of enantiomers by one transformation. To the best of our knowledge, this feature (conversion of regioisomers to enantiomers) has never been applied to natural product synthesis, and proved to be very valuable, since it allowed to obtain both optical antipodes of parvineostemonine in a single synthetic campaign. This not only enabled the determination of the previously undisclosed absolute configuration of the natural product, but gave 60-200 mg amounts of both enantiomers of the natural product.

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540 Chemie
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cycloaddition, natural products, oxidopyridinium ion, stemona alkaloids, total synth esis
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ISO 690GERLINGER, Christa K. G., Sebastian KRÜGER, Tanja GAICH, 2018. Total Synthesis of Parvineostemonine by Structure Pattern Recognition : A Unified Approach to Stemona and Sarpagine Alkaloids. In: Chemistry - A European Journal. 2018, 24(16), pp. 3994-3997. ISSN 0947-6539. eISSN 1521-3765. Available under: doi: 10.1002/chem.201800365
BibTex
@article{Gerlinger2018-03-15Total-41770,
  year={2018},
  doi={10.1002/chem.201800365},
  title={Total Synthesis of Parvineostemonine by Structure Pattern Recognition : A Unified Approach to Stemona and Sarpagine Alkaloids},
  number={16},
  volume={24},
  issn={0947-6539},
  journal={Chemistry - A European Journal},
  pages={3994--3997},
  author={Gerlinger, Christa K. G. and Krüger, Sebastian and Gaich, Tanja}
}
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