Formation of the bicoid morphogen gradient : an mRNA gradient dictates the protein gradient

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2009
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Spirov, Alexander
Fahmy, Khalid
Schneider, Martina
Frei, Erich
Noll, Markus
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Development. Company of Biologists. 2009, 136(4), pp. 605-614. ISSN 0950-1991. eISSN 1477-9129. Available under: doi: 10.1242/dev.031195
Zusammenfassung

The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole. However, we previously published evidence that the Bcd gradient is preceded by a bcd mRNA gradient. Here, we have revisited and extended this observation by showing that the bcd mRNA and Bcd protein gradient profiles are virtually identical at all times. This confirms our previous conclusion that the Bcd gradient is produced by a bcd mRNA gradient rather than by diffusion. Based on our observation that bcd mRNA colocalizes with Staufen (Stau), we propose that the bcd mRNA gradient forms by a novel mechanism involving quasi-random active transport of a Stau-bcd mRNA complex through a nonpolar microtubular network, which confines the bcd mRNA to the cortex of the embryo.

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570 Biowissenschaften, Biologie
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bicoid, Morphogenetic gradient, Staufen, ARTS model
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ISO 690SPIROV, Alexander, Khalid FAHMY, Martina SCHNEIDER, Erich FREI, Markus NOLL, Stefan BAUMGARTNER, 2009. Formation of the bicoid morphogen gradient : an mRNA gradient dictates the protein gradient. In: Development. Company of Biologists. 2009, 136(4), pp. 605-614. ISSN 0950-1991. eISSN 1477-9129. Available under: doi: 10.1242/dev.031195
BibTex
@article{Spirov2009-02-15Forma-50997,
  year={2009},
  doi={10.1242/dev.031195},
  title={Formation of the bicoid morphogen gradient : an mRNA gradient dictates the protein gradient},
  number={4},
  volume={136},
  issn={0950-1991},
  journal={Development},
  pages={605--614},
  author={Spirov, Alexander and Fahmy, Khalid and Schneider, Martina and Frei, Erich and Noll, Markus and Baumgartner, Stefan}
}
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