Interactions of non-polar and "click-able" nucleotides in the confines of a DNA polymerase active site

Ludmann, Samra; Bußkamp, Holger; Welte, Wolfram; Diederichs, Kay; Marx, Andreas

Interactions of non-polar and "click-able" nucleotides in the confines of a DNA polymerase active site

Dateien

Obeid_204941.pdfGröße: 1.54 MBDownloads: 612

Datum

2012

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie
Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Chemical Communications. 2012, 48(67), pp. 8320-8322. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/C2CC34181F

Zusammenfassung

Modified nucleotides play a paramount role in many cuttingedge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar "Click-able" nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

LUDMANN, Samra, Holger BUSSKAMP, Wolfram WELTE, Kay DIEDERICHS, Andreas MARX, 2012. Interactions of non-polar and "click-able" nucleotides in the confines of a DNA polymerase active site. In: Chemical Communications. 2012, 48(67), pp. 8320-8322. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/C2CC34181F

BibTex

@article{Ludmann2012-08-28Inter-20494,
  year={2012},
  doi={10.1039/C2CC34181F},
  title={Interactions of non-polar and "click-able" nucleotides in the confines of a DNA polymerase active site},
  number={67},
  volume={48},
  issn={1359-7345},
  journal={Chemical Communications},
  pages={8320--8322},
  author={Ludmann, Samra and Bußkamp, Holger and Welte, Wolfram and Diederichs, Kay and Marx, Andreas}
}

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