Hair cortisol analysis as a marker of past adverse experiences in adult patients with severe mental illness
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Both altered hypothalamic–pituitary–adrenal (HPA) axis activity and the exposure to adverse childhood experiences (ACE) have been repetitively documented in mental illness. Recent studies describe the impact of past environmental stress on hair cortisol using dose-dependent models: with increasing number of traumatic experiences, lower, but also higher hair cortisol levels have been observed. Besides the dose-dependent effect, recent evidence indicates a distinctive impact of type and timing of ACE on the developing organism, supporting the notion of stress-sensitive periods in (brain) development. The specific contribution of types and timings of adversities needs further evaluation for the alternations of HPA axis. The presented study evaluates the impact of childhood adversities on hair cortisol in patients with severe mental illness. Novel aspects were a detailed screening of various intrafamilial and peer-related types of adversities together with their timing in childhood and adolescence (using the retrospective assessment with the Maltreatment and Abuse Chronology of Exposure, MACE Scale), as well as a fine-grained analysis of predictive modeling of hair cortisol levels using conditioned forest regression.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
SCHALINSKI, Inga, 2016. Hair cortisol analysis as a marker of past adverse experiences in adult patients with severe mental illness. In: Psychoneuroendocrinology. 2016, 71(Supplement), pp. 73. ISSN 0306-4530. eISSN 1873-3360. Available under: doi: 10.1016/j.psyneuen.2016.07.189BibTex
@misc{Schalinski2016-09corti-36832, year={2016}, doi={10.1016/j.psyneuen.2016.07.189}, title={Hair cortisol analysis as a marker of past adverse experiences in adult patients with severe mental illness}, author={Schalinski, Inga} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36832"> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dcterms:abstract xml:lang="eng">Both altered hypothalamic–pituitary–adrenal (HPA) axis activity and the exposure to adverse childhood experiences (ACE) have been repetitively documented in mental illness. Recent studies describe the impact of past environmental stress on hair cortisol using dose-dependent models: with increasing number of traumatic experiences, lower, but also higher hair cortisol levels have been observed. Besides the dose-dependent effect, recent evidence indicates a distinctive impact of type and timing of ACE on the developing organism, supporting the notion of stress-sensitive periods in (brain) development. The specific contribution of types and timings of adversities needs further evaluation for the alternations of HPA axis. The presented study evaluates the impact of childhood adversities on hair cortisol in patients with severe mental illness. Novel aspects were a detailed screening of various intrafamilial and peer-related types of adversities together with their timing in childhood and adolescence (using the retrospective assessment with the Maltreatment and Abuse Chronology of Exposure, MACE Scale), as well as a fine-grained analysis of predictive modeling of hair cortisol levels using conditioned forest regression.</dcterms:abstract> <dcterms:issued>2016-09</dcterms:issued> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-19T09:13:08Z</dc:date> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/36832"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/> <dc:creator>Schalinski, Inga</dc:creator> <dcterms:title>Hair cortisol analysis as a marker of past adverse experiences in adult patients with severe mental illness</dcterms:title> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-19T09:13:08Z</dcterms:available> <dc:contributor>Schalinski, Inga</dc:contributor> </rdf:Description> </rdf:RDF>