An evolutionary basis for scrapie disease : identification of a fish prion mRNA

Rivera-Milla, Eric; Stürmer, Claudia; Málaga-Trillo, Edward

An evolutionary basis for scrapie disease : identification of a fish prion mRNA

Dateien

98_An_evolutionary_basis_for_Scrapie.pdfGröße: 427.71 KBDownloads: 1085

Datum

2003

Autor:innen

Rivera-Milla, Eric

Stürmer, Claudia

Málaga-Trillo, Edward

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Trends in Genetics. 2003, 19(2), pp. 72-75. ISSN 0168-9525. Available under: doi: 10.1016/S0168-9525(02)00032-X

Zusammenfassung

Infectious prion proteins cause neurodegenerative disease in mammals owing to the acquisition of an aberrant conformation. We cloned a Fugu rubripes gene that encodes a structurally conserved prion protein, and found rapid rates of molecular divergence among prions from different vertebrate classes, along with molecular stasis within each class. We propose that a directional trend in the evolution of prion sequence motifs associated with pathogenesis and infectivity could account for the origin of scrapie in mammals.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

RIVERA-MILLA, Eric, Claudia STÜRMER, Edward MÁLAGA-TRILLO, 2003. An evolutionary basis for scrapie disease : identification of a fish prion mRNA. In: Trends in Genetics. 2003, 19(2), pp. 72-75. ISSN 0168-9525. Available under: doi: 10.1016/S0168-9525(02)00032-X

BibTex

@article{RiveraMilla2003evolu-6715,
  year={2003},
  doi={10.1016/S0168-9525(02)00032-X},
  title={An evolutionary basis for scrapie disease : identification of a fish prion mRNA},
  number={2},
  volume={19},
  issn={0168-9525},
  journal={Trends in Genetics},
  pages={72--75},
  author={Rivera-Milla, Eric and Stürmer, Claudia and Málaga-Trillo, Edward}
}

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