An evolutionary basis for scrapie disease : identification of a fish prion mRNA

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2003
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Trends in Genetics. 2003, 19(2), pp. 72-75. ISSN 0168-9525. Available under: doi: 10.1016/S0168-9525(02)00032-X
Zusammenfassung

Infectious prion proteins cause neurodegenerative disease in mammals owing to the acquisition of an aberrant conformation. We cloned a Fugu rubripes gene that encodes a structurally conserved prion protein, and found rapid rates of molecular divergence among prions from different vertebrate classes, along with molecular stasis within each class. We propose that a directional trend in the evolution of prion sequence motifs associated with pathogenesis and infectivity could account for the origin of scrapie in mammals.

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570 Biowissenschaften, Biologie
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ISO 690RIVERA-MILLA, Eric, Claudia STÜRMER, Edward MÁLAGA-TRILLO, 2003. An evolutionary basis for scrapie disease : identification of a fish prion mRNA. In: Trends in Genetics. 2003, 19(2), pp. 72-75. ISSN 0168-9525. Available under: doi: 10.1016/S0168-9525(02)00032-X
BibTex
@article{RiveraMilla2003evolu-6715,
  year={2003},
  doi={10.1016/S0168-9525(02)00032-X},
  title={An evolutionary basis for scrapie disease : identification of a fish prion mRNA},
  number={2},
  volume={19},
  issn={0168-9525},
  journal={Trends in Genetics},
  pages={72--75},
  author={Rivera-Milla, Eric and Stürmer, Claudia and Málaga-Trillo, Edward}
}
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