Publikation: An evolutionary basis for scrapie disease : identification of a fish prion mRNA
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2003
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Trends in Genetics. 2003, 19(2), pp. 72-75. ISSN 0168-9525. Available under: doi: 10.1016/S0168-9525(02)00032-X
Zusammenfassung
Infectious prion proteins cause neurodegenerative disease in mammals owing to the acquisition of an aberrant conformation. We cloned a Fugu rubripes gene that encodes a structurally conserved prion protein, and found rapid rates of molecular divergence among prions from different vertebrate classes, along with molecular stasis within each class. We propose that a directional trend in the evolution of prion sequence motifs associated with pathogenesis and infectivity could account for the origin of scrapie in mammals.
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570 Biowissenschaften, Biologie
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RIVERA-MILLA, Eric, Claudia STÜRMER, Edward MÁLAGA-TRILLO, 2003. An evolutionary basis for scrapie disease : identification of a fish prion mRNA. In: Trends in Genetics. 2003, 19(2), pp. 72-75. ISSN 0168-9525. Available under: doi: 10.1016/S0168-9525(02)00032-XBibTex
@article{RiveraMilla2003evolu-6715,
year={2003},
doi={10.1016/S0168-9525(02)00032-X},
title={An evolutionary basis for scrapie disease : identification of a fish prion mRNA},
number={2},
volume={19},
issn={0168-9525},
journal={Trends in Genetics},
pages={72--75},
author={Rivera-Milla, Eric and Stürmer, Claudia and Málaga-Trillo, Edward}
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<dcterms:abstract xml:lang="eng">Infectious prion proteins cause neurodegenerative disease in mammals owing to the acquisition of an aberrant conformation. We cloned a Fugu rubripes gene that encodes a structurally conserved prion protein, and found rapid rates of molecular divergence among prions from different vertebrate classes, along with molecular stasis within each class. We propose that a directional trend in the evolution of prion sequence motifs associated with pathogenesis and infectivity could account for the origin of scrapie in mammals.</dcterms:abstract>
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