Publikation:

DNA methylation regulates transcriptional homeostasis of algal endosymbiosis in the coral model Aiptasia

Vorschaubild

Dateien

Li_2-u2l5qm2jvqkf3.pdf
Li_2-u2l5qm2jvqkf3.pdfGröße: 1.28 MBDownloads: 191

Datum

2018

Autor:innen

Li, Yong
Liew, Yi Jin
Cui, Guoxin
Cziesielski, Maha J.
Zahran, Noura
Michell, Craig T.
Aranda, Manuel

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-u2l5qm2jvqkf3
DOI (zitierfähiger Link)
https://doi.org/10.1126/sciadv.aat2142
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz

CC BY-NC 4.0

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Gold

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Science Advances. American Association for the Advancement of Science (AAAS). 2018, 4(8), eaat2142. eISSN 2375-2548. Available under: doi: 10.1126/sciadv.aat2142

Zusammenfassung

The symbiotic relationship between cnidarians and dinoflagellates is the cornerstone of coral reef ecosystems. Although research has focused on the molecular mechanisms underlying this symbiosis, the role of epigenetic mechanisms, that is, the study of heritable changes that do not involve changes in the DNA sequence, is unknown. To assess the role of DNA methylation in the cnidarian-dinoflagellate symbiosis, we analyzed genome-wide CpG methylation, histone associations, and transcriptomic states of symbiotic and aposymbiotic anemones in the model system Aiptasia. We found that methylated genes are marked by histone 3 lysine 36 trimethylation (H3K36me3) and show significant reduction of spurious transcription and transcriptional noise, revealing a role of DNA methylation in the maintenance of transcriptional homeostasis. Changes in DNA methylation and expression show enrichment for symbiosis-related processes, such as immunity, apoptosis, phagocytosis recognition, and phagosome formation, and reveal intricate interactions between the underlying pathways. Our results demonstrate that DNA methylation provides an epigenetic mechanism of transcriptional homeostasis that responds to symbiosis.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Verknüpfte Datensätze

Zitieren

ISO 690LI, Yong, Yi Jin LIEW, Guoxin CUI, Maha J. CZIESIELSKI, Noura ZAHRAN, Craig T. MICHELL, Christian R. VOOLSTRA, Manuel ARANDA, 2018. DNA methylation regulates transcriptional homeostasis of algal endosymbiosis in the coral model Aiptasia. In: Science Advances. American Association for the Advancement of Science (AAAS). 2018, 4(8), eaat2142. eISSN 2375-2548. Available under: doi: 10.1126/sciadv.aat2142
BibTex
@article{Li2018methy-51031,
  year={2018},
  doi={10.1126/sciadv.aat2142},
  title={DNA methylation regulates transcriptional homeostasis of algal endosymbiosis in the coral model Aiptasia},
  number={8},
  volume={4},
  journal={Science Advances},
  author={Li, Yong and Liew, Yi Jin and Cui, Guoxin and Cziesielski, Maha J. and Zahran, Noura and Michell, Craig T. and Voolstra, Christian R. and Aranda, Manuel},
  note={Article Number: eaat2142}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/51031">
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc/4.0/"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-25T08:28:42Z</dc:date>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-25T08:28:42Z</dcterms:available>
    <dc:creator>Voolstra, Christian R.</dc:creator>
    <dc:creator>Michell, Craig T.</dc:creator>
    <dc:contributor>Li, Yong</dc:contributor>
    <dcterms:title>DNA methylation regulates transcriptional homeostasis of algal endosymbiosis in the coral model Aiptasia</dcterms:title>
    <dc:creator>Zahran, Noura</dc:creator>
    <dc:creator>Cziesielski, Maha J.</dc:creator>
    <dcterms:issued>2018</dcterms:issued>
    <dc:creator>Cui, Guoxin</dc:creator>
    <dc:contributor>Cui, Guoxin</dc:contributor>
    <dc:contributor>Liew, Yi Jin</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/51031"/>
    <dcterms:abstract xml:lang="eng">The symbiotic relationship between cnidarians and dinoflagellates is the cornerstone of coral reef ecosystems. Although research has focused on the molecular mechanisms underlying this symbiosis, the role of epigenetic mechanisms, that is, the study of heritable changes that do not involve changes in the DNA sequence, is unknown. To assess the role of DNA methylation in the cnidarian-dinoflagellate symbiosis, we analyzed genome-wide CpG methylation, histone associations, and transcriptomic states of symbiotic and aposymbiotic anemones in the model system Aiptasia. We found that methylated genes are marked by histone 3 lysine 36 trimethylation (H3K36me3) and show significant reduction of spurious transcription and transcriptional noise, revealing a role of DNA methylation in the maintenance of transcriptional homeostasis. Changes in DNA methylation and expression show enrichment for symbiosis-related processes, such as immunity, apoptosis, phagocytosis recognition, and phagosome formation, and reveal intricate interactions between the underlying pathways. Our results demonstrate that DNA methylation provides an epigenetic mechanism of transcriptional homeostasis that responds to symbiosis.</dcterms:abstract>
    <dc:creator>Li, Yong</dc:creator>
    <dc:contributor>Cziesielski, Maha J.</dc:contributor>
    <dc:contributor>Aranda, Manuel</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/51031/5/Li_2-u2l5qm2jvqkf3.pdf"/>
    <dc:creator>Aranda, Manuel</dc:creator>
    <dc:contributor>Zahran, Noura</dc:contributor>
    <dc:language>eng</dc:language>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Michell, Craig T.</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Liew, Yi Jin</dc:creator>
    <dc:rights>Attribution-NonCommercial 4.0 International</dc:rights>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Voolstra, Christian R.</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/51031/5/Li_2-u2l5qm2jvqkf3.pdf"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Ja
Diese Publikation teilen