@article{Hengstermann2005-07Growt-16768,
  year={2005},
  doi={10.1128/JVI.79.14.9296-9300.2005},
  title={Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53},
  number={14},
  volume={79},
  issn={0022-538X},
  journal={Journal of Virology},
  pages={9296--9300},
  author={Hengstermann, Arnd and D'silva, Michael A. and Kuballa, Petric and Butz, Karin and Hoppe-Seyler, Felix and Scheffner, Martin}
}

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    <dc:creator>Scheffner, Martin</dc:creator>
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    <dc:creator>Hengstermann, Arnd</dc:creator>
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    <dcterms:title>Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53</dcterms:title>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-16T08:24:37Z</dc:date>
    <dc:creator>Hoppe-Seyler, Felix</dc:creator>
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    <dc:language>eng</dc:language>
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    <dc:creator>Butz, Karin</dc:creator>
    <dcterms:abstract xml:lang="eng">The ubiquitin-protein ligase E6-AP is utilized by the E6 oncoprotein of human papillomaviruses (HPVs) associated with cervical cancer to target the tumor suppressor p53 for degradation. Here, we report that downregulation of E6-AP expression by RNA interference results in both the accumulation of p53 and growth suppression of the HPV-positive cervical cancer cell lines HeLa and SiHa. In addition, HeLa cells, in which p53 expression was suppressed by RNA interference, are significantly less sensitive to the downregulation of E6-AP expression with respect to growth suppression than parental HeLa cells. These data indicate that the anti-growth-suppressive properties of E6-AP in HPV-positive cells depend on its ability to induce p53 degradation.</dcterms:abstract>
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    <dc:contributor>Butz, Karin</dc:contributor>
    <dc:creator>Kuballa, Petric</dc:creator>
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    <dc:contributor>D'silva, Michael A.</dc:contributor>
    <dcterms:bibliographicCitation>Publ. in: Journal of Virology ; 79 (2005), 14. - S. 9296-9300</dcterms:bibliographicCitation>
    <dc:contributor>Hoppe-Seyler, Felix</dc:contributor>
    <dc:creator>D'silva, Michael A.</dc:creator>
    <dc:contributor>Kuballa, Petric</dc:contributor>
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