Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53

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2005
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Hengstermann, Arnd
D'silva, Michael A.
Kuballa, Petric
Butz, Karin
Hoppe-Seyler, Felix
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Journal of Virology. 2005, 79(14), pp. 9296-9300. ISSN 0022-538X. Available under: doi: 10.1128/JVI.79.14.9296-9300.2005
Zusammenfassung

The ubiquitin-protein ligase E6-AP is utilized by the E6 oncoprotein of human papillomaviruses (HPVs) associated with cervical cancer to target the tumor suppressor p53 for degradation. Here, we report that downregulation of E6-AP expression by RNA interference results in both the accumulation of p53 and growth suppression of the HPV-positive cervical cancer cell lines HeLa and SiHa. In addition, HeLa cells, in which p53 expression was suppressed by RNA interference, are significantly less sensitive to the downregulation of E6-AP expression with respect to growth suppression than parental HeLa cells. These data indicate that the anti-growth-suppressive properties of E6-AP in HPV-positive cells depend on its ability to induce p53 degradation.

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570 Biowissenschaften, Biologie
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ISO 690HENGSTERMANN, Arnd, Michael A. D'SILVA, Petric KUBALLA, Karin BUTZ, Felix HOPPE-SEYLER, Martin SCHEFFNER, 2005. Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53. In: Journal of Virology. 2005, 79(14), pp. 9296-9300. ISSN 0022-538X. Available under: doi: 10.1128/JVI.79.14.9296-9300.2005
BibTex
@article{Hengstermann2005-07Growt-16768,
  year={2005},
  doi={10.1128/JVI.79.14.9296-9300.2005},
  title={Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53},
  number={14},
  volume={79},
  issn={0022-538X},
  journal={Journal of Virology},
  pages={9296--9300},
  author={Hengstermann, Arnd and D'silva, Michael A. and Kuballa, Petric and Butz, Karin and Hoppe-Seyler, Felix and Scheffner, Martin}
}
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