Publikation: Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53
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2005
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Journal of Virology. 2005, 79(14), pp. 9296-9300. ISSN 0022-538X. Available under: doi: 10.1128/JVI.79.14.9296-9300.2005
Zusammenfassung
The ubiquitin-protein ligase E6-AP is utilized by the E6 oncoprotein of human papillomaviruses (HPVs) associated with cervical cancer to target the tumor suppressor p53 for degradation. Here, we report that downregulation of E6-AP expression by RNA interference results in both the accumulation of p53 and growth suppression of the HPV-positive cervical cancer cell lines HeLa and SiHa. In addition, HeLa cells, in which p53 expression was suppressed by RNA interference, are significantly less sensitive to the downregulation of E6-AP expression with respect to growth suppression than parental HeLa cells. These data indicate that the anti-growth-suppressive properties of E6-AP in HPV-positive cells depend on its ability to induce p53 degradation.
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570 Biowissenschaften, Biologie
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HENGSTERMANN, Arnd, Michael A. D'SILVA, Petric KUBALLA, Karin BUTZ, Felix HOPPE-SEYLER, Martin SCHEFFNER, 2005. Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53. In: Journal of Virology. 2005, 79(14), pp. 9296-9300. ISSN 0022-538X. Available under: doi: 10.1128/JVI.79.14.9296-9300.2005BibTex
@article{Hengstermann2005-07Growt-16768,
year={2005},
doi={10.1128/JVI.79.14.9296-9300.2005},
title={Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53},
number={14},
volume={79},
issn={0022-538X},
journal={Journal of Virology},
pages={9296--9300},
author={Hengstermann, Arnd and D'silva, Michael A. and Kuballa, Petric and Butz, Karin and Hoppe-Seyler, Felix and Scheffner, Martin}
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<dcterms:abstract xml:lang="eng">The ubiquitin-protein ligase E6-AP is utilized by the E6 oncoprotein of human papillomaviruses (HPVs) associated with cervical cancer to target the tumor suppressor p53 for degradation. Here, we report that downregulation of E6-AP expression by RNA interference results in both the accumulation of p53 and growth suppression of the HPV-positive cervical cancer cell lines HeLa and SiHa. In addition, HeLa cells, in which p53 expression was suppressed by RNA interference, are significantly less sensitive to the downregulation of E6-AP expression with respect to growth suppression than parental HeLa cells. These data indicate that the anti-growth-suppressive properties of E6-AP in HPV-positive cells depend on its ability to induce p53 degradation.</dcterms:abstract>
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