Protein quality control systems in muscle : From disease to mechanism

Markovic, Marija

Protein quality control systems in muscle : From disease to mechanism

Dateien

Markovic_2-u5fj7kdmkfln7.pdfGröße: 11.1 MBDownloads: 51

Datum

2020

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie
Chemie

Publikationstyp

Dissertation

Publikationsstatus

Published

Zusammenfassung

The myofibril is among the most organized macromolecular structures in eukaryotes and it is maintained by intricately balanced protein quality control (PQCs) pathways of chaperone-mediated protein folding and ubiquitin-proteasome degradation. Although the main players of the PQCs are well studied, the exact mechanisms by which they recognize clients and control processes remain obscure. The presented research focuses on two distinct muscle disease models - muscle atrophy and dilated cardiomyopathy - in order to reveal the underlying mechanisms that control Muscle RING Finger protein 1 (MuRF1) dependent ubiquitination and Nucleotide Exchange Factor (NEF) BAG3 mediated protein refolding by combining X-ray crystallography with biochemical assays and biophysical methods.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

muscle, crystallography, myosin, titin, sarcomere, BLI, ubiquitination, protein quality control, structure, E3-ubiquitin ligase, RING finger, single muscle fiber

Zitieren

ISO 690

MARKOVIC, Marija, 2020. Protein quality control systems in muscle : From disease to mechanism [Dissertation]. Konstanz: University of Konstanz

BibTex

@phdthesis{Markovic2020Prote-54043,
  year={2020},
  title={Protein quality control systems in muscle : From disease to mechanism},
  author={Markovic, Marija},
  address={Konstanz},
  school={Universität Konstanz}
}

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Prüfungsdatum der Dissertation

November 13, 2020

Hochschulschriftenvermerk

Konstanz, Univ., Diss., 2020

Universitätsbibliographie

Ja