Protein quality control systems in muscle : From disease to mechanism

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2020
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Zusammenfassung

The myofibril is among the most organized macromolecular structures in eukaryotes and it is maintained by intricately balanced protein quality control (PQCs) pathways of chaperone-mediated protein folding and ubiquitin-proteasome degradation. Although the main players of the PQCs are well studied, the exact mechanisms by which they recognize clients and control processes remain obscure. The presented research focuses on two distinct muscle disease models - muscle atrophy and dilated cardiomyopathy - in order to reveal the underlying mechanisms that control Muscle RING Finger protein 1 (MuRF1) dependent ubiquitination and Nucleotide Exchange Factor (NEF) BAG3 mediated protein refolding by combining X-ray crystallography with biochemical assays and biophysical methods.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
muscle, crystallography, myosin, titin, sarcomere, BLI, ubiquitination, protein quality control, structure, E3-ubiquitin ligase, RING finger, single muscle fiber
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ISO 690MARKOVIC, Marija, 2020. Protein quality control systems in muscle : From disease to mechanism [Dissertation]. Konstanz: University of Konstanz
BibTex
@phdthesis{Markovic2020Prote-54043,
  year={2020},
  title={Protein quality control systems in muscle : From disease to mechanism},
  author={Markovic, Marija},
  address={Konstanz},
  school={Universität Konstanz}
}
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URL der Originalveröffentl.
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Prüfungsdatum der Dissertation
November 13, 2020
Hochschulschriftenvermerk
Konstanz, Univ., Diss., 2020
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