Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
1999
Autor:innen
Schierle, Gabriele S. Kaminski
Hansson, Oskar
Brundin, Patrik
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
NeuroReport. 1999, 10(16), pp. 3347-3351. ISSN 0959-4965. eISSN 1473-558X
Zusammenfassung

The exact causes of the extensive cell death in nigral transplants are still unknown. Since poly-(ADP-ribose) polymerase (PARP) overactivation has been implicated in neuronal death, we examined the effects of PARP on the survival of nigral grafts by using donor tissue from PARP knock-out or wild-type mice. Eight hours after preparation of the nigral cell suspension, cell damage was quantified by measurement of lactate dehydrogenase release, DNA fragmentation and caspase activation. At this stage, PARP deletion had no protective effect. Moreover, neither the survival of transplanted dopaminergic neurons, nor the functional recovery of hemiparkinsonian graft recipients were improved by the absence of PARP. We conclude that cell death in embryonic nigral grafts is not affected by the absence of PARP activation.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Apoptosis, Dopamine, Necrosis, Neural transplantation, Parkinson's disease, PARP, Substantia nigra
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690SCHIERLE, Gabriele S. Kaminski, Oskar HANSSON, Elisa FERRANDO-MAY, Pierluigi NICOTERA, Patrik BRUNDIN, Marcel LEIST, 1999. Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation. In: NeuroReport. 1999, 10(16), pp. 3347-3351. ISSN 0959-4965. eISSN 1473-558X
BibTex
@article{Schierle1999Neuro-22370,
  year={1999},
  title={Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation},
  number={16},
  volume={10},
  issn={0959-4965},
  journal={NeuroReport},
  pages={3347--3351},
  author={Schierle, Gabriele S. Kaminski and Hansson, Oskar and Ferrando-May, Elisa and Nicotera, Pierluigi and Brundin, Patrik and Leist, Marcel}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/22370">
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:issued>1999</dcterms:issued>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Schierle, Gabriele S. Kaminski</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-04-03T09:55:46Z</dcterms:available>
    <dc:contributor>Hansson, Oskar</dc:contributor>
    <dc:contributor>Ferrando-May, Elisa</dc:contributor>
    <dcterms:bibliographicCitation>NeuroReport ; 10 (1999), 16. - S. 3347-3351</dcterms:bibliographicCitation>
    <dc:contributor>Schierle, Gabriele S. Kaminski</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/22370/1/Schierle_223706.pdf"/>
    <dc:contributor>Brundin, Patrik</dc:contributor>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Leist, Marcel</dc:creator>
    <dc:creator>Brundin, Patrik</dc:creator>
    <dcterms:title>Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation</dcterms:title>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:abstract xml:lang="eng">The exact causes of the extensive cell death in nigral transplants are still unknown. Since poly-(ADP-ribose) polymerase (PARP) overactivation has been implicated in neuronal death, we examined the effects of PARP on the survival of nigral grafts by using donor tissue from PARP knock-out or wild-type mice. Eight hours after preparation of the nigral cell suspension, cell damage was quantified by measurement of lactate dehydrogenase release, DNA fragmentation and caspase activation. At this stage, PARP deletion had no protective effect. Moreover, neither the survival of transplanted dopaminergic neurons, nor the functional recovery of hemiparkinsonian graft recipients were improved by the absence of PARP. We conclude that cell death in embryonic nigral grafts is not affected by the absence of PARP activation.</dcterms:abstract>
    <dc:contributor>Nicotera, Pierluigi</dc:contributor>
    <dc:creator>Hansson, Oskar</dc:creator>
    <dc:creator>Nicotera, Pierluigi</dc:creator>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22370"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/22370/1/Schierle_223706.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:language>eng</dc:language>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-04-03T09:55:46Z</dc:date>
    <dc:creator>Ferrando-May, Elisa</dc:creator>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen