Publikation: Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation
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Datum
1999
Autor:innen
Schierle, Gabriele S. Kaminski
Hansson, Oskar
Brundin, Patrik
Herausgeber:innen
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Published
Erschienen in
NeuroReport. 1999, 10(16), pp. 3347-3351. ISSN 0959-4965. eISSN 1473-558X
Zusammenfassung
The exact causes of the extensive cell death in nigral transplants are still unknown. Since poly-(ADP-ribose) polymerase (PARP) overactivation has been implicated in neuronal death, we examined the effects of PARP on the survival of nigral grafts by using donor tissue from PARP knock-out or wild-type mice. Eight hours after preparation of the nigral cell suspension, cell damage was quantified by measurement of lactate dehydrogenase release, DNA fragmentation and caspase activation. At this stage, PARP deletion had no protective effect. Moreover, neither the survival of transplanted dopaminergic neurons, nor the functional recovery of hemiparkinsonian graft recipients were improved by the absence of PARP. We conclude that cell death in embryonic nigral grafts is not affected by the absence of PARP activation.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Apoptosis, Dopamine, Necrosis, Neural transplantation, Parkinson's disease, PARP, Substantia nigra
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SCHIERLE, Gabriele S. Kaminski, Oskar HANSSON, Elisa FERRANDO-MAY, Pierluigi NICOTERA, Patrik BRUNDIN, Marcel LEIST, 1999. Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation. In: NeuroReport. 1999, 10(16), pp. 3347-3351. ISSN 0959-4965. eISSN 1473-558XBibTex
@article{Schierle1999Neuro-22370,
year={1999},
title={Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation},
number={16},
volume={10},
issn={0959-4965},
journal={NeuroReport},
pages={3347--3351},
author={Schierle, Gabriele S. Kaminski and Hansson, Oskar and Ferrando-May, Elisa and Nicotera, Pierluigi and Brundin, Patrik and Leist, Marcel}
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<dcterms:abstract xml:lang="eng">The exact causes of the extensive cell death in nigral transplants are still unknown. Since poly-(ADP-ribose) polymerase (PARP) overactivation has been implicated in neuronal death, we examined the effects of PARP on the survival of nigral grafts by using donor tissue from PARP knock-out or wild-type mice. Eight hours after preparation of the nigral cell suspension, cell damage was quantified by measurement of lactate dehydrogenase release, DNA fragmentation and caspase activation. At this stage, PARP deletion had no protective effect. Moreover, neither the survival of transplanted dopaminergic neurons, nor the functional recovery of hemiparkinsonian graft recipients were improved by the absence of PARP. We conclude that cell death in embryonic nigral grafts is not affected by the absence of PARP activation.</dcterms:abstract>
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