Critical evaluation of the use of dogs in biomedical research and testing in Europe

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Hasiwa_181456.pdf
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2011
Autor:innen
Bailey, Jarrod
Clausing, Peter
Eileraas, Marianne
Farkas, Sándor
Gyertyán, István
Hubrecht, Robert
Kobel, Werner
Krummenacher, Goran
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Alternatives to animal experimentation : ALTEX. 2011, 28(4), pp. 326-340. ISSN 1868-596X. Available under: doi: 10.14573/altex.2011.4.326
Zusammenfassung

Dogs are sometimes referred to as “man’s best friend” and with the increase in urbanization and lifestyle changes, dogs are seen by their owners as family members. Society expresses specific concerns about the experimental use of dogs, as they are sometimes perceived to have a special status for humans. This may appear somewhat conflicting with the idea that the intrinsic value of all animals is the same, and that also several other animal species are used in biomedical research and toxicology. This aspect and many others are discussed in an introductory chapter dealing with ethical considerations on the use of dogs as laboratory animals. The report gives an overview on the use of dogs in biomedical research, safety assessment and the drug developmental process and reflects the discussion on the use of dogs as second (non-rodent)species in toxicity testing. Approximately 20,000 dogs are used in scientific procedures in Europe every year, and their distinct genetic, physiological and behavioral characteristics may support their use as models for e.g. behavioral analysis and genetic research. Advances in the 3Rs (Replacement, Reduction and Refinement of experiments using dogs) are described, potential opportunities are discussed and recommendations for further progress in this area are made.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
dog use, animal welfare, moral dilemma, second species paradigm, 3Rs
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ISO 690HASIWA, Nina, Jarrod BAILEY, Peter CLAUSING, Mardas DANESHIAN, Marianne EILERAAS, Sándor FARKAS, István GYERTYÁN, Robert HUBRECHT, Werner KOBEL, Goran KRUMMENACHER, Marcel LEIST, Hannes LOHI, Ádám MIKLÓSI, Frauke OHL, Klaus OLEJNICZAK, Georg SCHMITT, Patrick SINNETT-SMITH, David SMITH, Kristina WAGNER, James D. YAGER, Joanne ZURLO, Thomas HARTUNG, 2011. Critical evaluation of the use of dogs in biomedical research and testing in Europe. In: Alternatives to animal experimentation : ALTEX. 2011, 28(4), pp. 326-340. ISSN 1868-596X. Available under: doi: 10.14573/altex.2011.4.326
BibTex
@article{Hasiwa2011Criti-18145,
  year={2011},
  doi={10.14573/altex.2011.4.326},
  title={Critical evaluation of the use of dogs in biomedical research and testing in Europe},
  number={4},
  volume={28},
  issn={1868-596X},
  journal={Alternatives to animal experimentation : ALTEX},
  pages={326--340},
  author={Hasiwa, Nina and Bailey, Jarrod and Clausing, Peter and Daneshian, Mardas and Eileraas, Marianne and Farkas, Sándor and Gyertyán, István and Hubrecht, Robert and Kobel, Werner and Krummenacher, Goran and Leist, Marcel and Lohi, Hannes and Miklósi, Ádám and Ohl, Frauke and Olejniczak, Klaus and Schmitt, Georg and Sinnett-Smith, Patrick and Smith, David and Wagner, Kristina and Yager, James D. and Zurlo, Joanne and Hartung, Thomas}
}
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