Publikation: Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides
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2013
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Journal of the American Chemical Society. 2013, 135(42), pp. 15667-15669. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja405346s
Zusammenfassung
Functional nucleotides are important in many cutting-edge biomolecular techniques. Often several modified nucleotides have to be incorporated consecutively. This structural study of KlenTaq DNA polymerase, a truncated form of Thermus aquaticus DNA polymerase, gives first insights how multiple modifications are processed by a DNA polymerase and, therefore, contribute to the understanding of these enzymes in their interplay with artificial substrates.
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570 Biowissenschaften, Biologie
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LUDMANN, Samra, Holger BUSSKAMP, Wolfram WELTE, Kay DIEDERICHS, Andreas MARX, 2013. Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides. In: Journal of the American Chemical Society. 2013, 135(42), pp. 15667-15669. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja405346sBibTex
@article{Ludmann2013-10-23Snaps-25126,
year={2013},
doi={10.1021/ja405346s},
title={Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides},
number={42},
volume={135},
issn={0002-7863},
journal={Journal of the American Chemical Society},
pages={15667--15669},
author={Ludmann, Samra and Bußkamp, Holger and Welte, Wolfram and Diederichs, Kay and Marx, Andreas}
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<dcterms:abstract xml:lang="eng">Functional nucleotides are important in many cutting-edge biomolecular techniques. Often several modified nucleotides have to be incorporated consecutively. This structural study of KlenTaq DNA polymerase, a truncated form of Thermus aquaticus DNA polymerase, gives first insights how multiple modifications are processed by a DNA polymerase and, therefore, contribute to the understanding of these enzymes in their interplay with artificial substrates.</dcterms:abstract>
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