Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides

Ludmann, Samra; Bußkamp, Holger; Welte, Wolfram; Diederichs, Kay; Marx, Andreas

Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides

Dateien

Obeid_251260.pdfGröße: 235.17 KBDownloads: 431

Datum

2013

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie
Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Journal of the American Chemical Society. 2013, 135(42), pp. 15667-15669. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja405346s

Zusammenfassung

Functional nucleotides are important in many cutting-edge biomolecular techniques. Often several modified nucleotides have to be incorporated consecutively. This structural study of KlenTaq DNA polymerase, a truncated form of Thermus aquaticus DNA polymerase, gives first insights how multiple modifications are processed by a DNA polymerase and, therefore, contribute to the understanding of these enzymes in their interplay with artificial substrates.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

LUDMANN, Samra, Holger BUSSKAMP, Wolfram WELTE, Kay DIEDERICHS, Andreas MARX, 2013. Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides. In: Journal of the American Chemical Society. 2013, 135(42), pp. 15667-15669. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja405346s

BibTex

@article{Ludmann2013-10-23Snaps-25126,
  year={2013},
  doi={10.1021/ja405346s},
  title={Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides},
  number={42},
  volume={135},
  issn={0002-7863},
  journal={Journal of the American Chemical Society},
  pages={15667--15669},
  author={Ludmann, Samra and Bußkamp, Holger and Welte, Wolfram and Diederichs, Kay and Marx, Andreas}
}

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