The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
The mycotoxin ochratoxin A (OTA) was shown to be a potent kidney carcinogen in rats demonstrating a marked sex difference in the response. Compared to female rats, male rats had a 10-fold higher incidence of kidney carcinomas. The objective of this study was to investigate whether this sex difference in tumor response is due to an exacerbation of effect resulting from the interaction of the male rat specific urinary protein α2u-globulin (α2u) with OTA. Male and female rats were treated by oral gavage with OTA (1 mg/kg per day), D-limonene (dL; 1650 mg/kg per day) as a positive control or corn oil for 7 consecutive days. OTA induced severe renal lesions predominantly in the P3 region of the proximal tubules. The lesions consisted of necrotic cells and cell exfoliations. No hyaline droplets were found in the P2 segment following OTA treatment, whereas dL induced the expected accumulation of droplets. The results suggest that OTA induced kidney lesions are in all characteristic points different from the known α2u-nephropathy induced by dL. Based on these experiments the male rat specific protein α2u does not seem to be involved in the mechanism(s) leading to the high tumor incidence observed in OTA exposed male rats.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
RÁSONYI, Thomas, Josef SCHLATTER, Daniel R. DIETRICH, 1999. The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats. In: Toxicology Letters. 1999, 104(1-2), pp. 83-92. ISSN 0378-4274. Available under: doi: 10.1016/S0378-4274(98)00347-6BibTex
@article{Rasonyi1999alpha-7815,
year={1999},
doi={10.1016/S0378-4274(98)00347-6},
title={The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats},
number={1-2},
volume={104},
issn={0378-4274},
journal={Toxicology Letters},
pages={83--92},
author={Rásonyi, Thomas and Schlatter, Josef and Dietrich, Daniel R.}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/7815">
<dc:contributor>Dietrich, Daniel R.</dc:contributor>
<dcterms:issued>1999</dcterms:issued>
<dc:language>eng</dc:language>
<dcterms:title>The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats</dcterms:title>
<dcterms:bibliographicCitation>First publ. in: Toxicology Letters 104 (1999), 1-2, pp. 83-92</dcterms:bibliographicCitation>
<dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
<dc:contributor>Schlatter, Josef</dc:contributor>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dc:creator>Dietrich, Daniel R.</dc:creator>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:37:44Z</dcterms:available>
<dc:contributor>Rásonyi, Thomas</dc:contributor>
<dc:creator>Rásonyi, Thomas</dc:creator>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7815/1/The_role_of_alpha2u.pdf"/>
<dc:creator>Schlatter, Josef</dc:creator>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7815"/>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7815/1/The_role_of_alpha2u.pdf"/>
<dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:37:44Z</dc:date>
<dcterms:abstract xml:lang="eng">The mycotoxin ochratoxin A (OTA) was shown to be a potent kidney carcinogen in rats demonstrating a marked sex difference in the response. Compared to female rats, male rats had a 10-fold higher incidence of kidney carcinomas. The objective of this study was to investigate whether this sex difference in tumor response is due to an exacerbation of effect resulting from the interaction of the male rat specific urinary protein α2u-globulin (α2u) with OTA. Male and female rats were treated by oral gavage with OTA (1 mg/kg per day), D-limonene (dL; 1650 mg/kg per day) as a positive control or corn oil for 7 consecutive days. OTA induced severe renal lesions predominantly in the P3 region of the proximal tubules. The lesions consisted of necrotic cells and cell exfoliations. No hyaline droplets were found in the P2 segment following OTA treatment, whereas dL induced the expected accumulation of droplets. The results suggest that OTA induced kidney lesions are in all characteristic points different from the known α2u-nephropathy induced by dL. Based on these experiments the male rat specific protein α2u does not seem to be involved in the mechanism(s) leading to the high tumor incidence observed in OTA exposed male rats.</dcterms:abstract>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dc:format>application/pdf</dc:format>
</rdf:Description>
</rdf:RDF>
