@article{Fleming2023-05-31Molec-67061,
  year={2023},
  doi={10.1007/s10974-023-09649-1},
  title={Molecular insights into titin’s A-band},
  number={4},
  volume={44},
  issn={0142-4319},
  journal={Journal of Muscle Research and Cell Motility},
  pages={255--270},
  author={Fleming, Jennifer R. and Müller, Iljas and Diederichs, Kay and Mayans, Olga and Zacharchenko, Thomas}
}

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    <dc:creator>Mayans, Olga</dc:creator>
    <dc:contributor>Zacharchenko, Thomas</dc:contributor>
    <dcterms:issued>2023-05-31</dcterms:issued>
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    <dc:creator>Zacharchenko, Thomas</dc:creator>
    <dc:creator>Diederichs, Kay</dc:creator>
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    <dcterms:title>Molecular insights into titin’s A-band</dcterms:title>
    <dc:language>eng</dc:language>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-06-05T06:14:50Z</dc:date>
    <dc:contributor>Müller, Iljas</dc:contributor>
    <dc:creator>Müller, Iljas</dc:creator>
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    <dcterms:abstract>The thick filament-associated A-band region of titin is a highly repetitive component of the titin chain with important scaffolding properties that support thick filament assembly. It also has a demonstrated link to human disease. Despite its functional significance, it remains a largely uncharacterized part of the titin protein. Here, we have performed an analysis of sequence and structure conservation of A-band titin, with emphasis on poly-FnIII tandem components. Specifically, we have applied multi-dimensional sequence pairwise similarity analysis to FnIII domains and complemented this with the crystallographic elucidation of the 3D-structure of the FnIII-triplet A84-A86 from the fourth long super-repeat in the C-zone (C4). Structural models serve here as templates to map sequence conservation onto super-repeat C4, which we show is a prototypical representative of titin’s C-zone. This templating identifies positionally conserved residue clusters in C super-repeats with the potential of mediating interactions to thick-filament components. Conservation localizes to two super-repeat positions: Ig domains in position 1 and FnIII domains in position 7. The analysis also allows conclusions to be drawn on the conserved architecture of titin’s A-band, as well as revisiting and expanding the evolutionary model of titin’s A-band.</dcterms:abstract>
    <dc:contributor>Mayans, Olga</dc:contributor>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dc:contributor>Diederichs, Kay</dc:contributor>
    <dc:creator>Fleming, Jennifer R.</dc:creator>
    <dc:contributor>Fleming, Jennifer R.</dc:contributor>
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