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Synthesis and characterization of DNA-functionalized calcium phosphate nanoparticles

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2006

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Sokolova, V.
Prymak, O.
Meyer-Zaika, W.
Rehage, H.
Shukla, A.
Epple, M.

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https://doi.org/10.1002/mawe.200600017
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Materialwissenschaft und Werkstofftechnik. 2006, 37(6), pp. 441-445. ISSN 0933-5137. eISSN 1521-4052. Available under: doi: 10.1002/mawe.200600017

Zusammenfassung

Calcium phosphate nanoparticles were prepared by precipitation from aqueous solution. A stable colloid was formed by coating with DNA. The properties of the colloidal dispersion can be adjusted by variation of the inorganic nanoparticles. In particular, the partial substitution of calcium by magnesium or aluminum led to stable dispersions of nanoparticles. By a multi-step precipitation process, it is also possible to include DNA into the particles in order to protect it from intracellular biochemical degradation. The dispersions were analyzed by dynamic light scattering, zeta potential measurements, analytical ultracentrifugation, and transmission electron microscopy.

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540 Chemie

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ISO 690SOKOLOVA, V., O. PRYMAK, W. MEYER-ZAIKA, Helmut CÖLFEN, H. REHAGE, A. SHUKLA, M. EPPLE, 2006. Synthesis and characterization of DNA-functionalized calcium phosphate nanoparticles. In: Materialwissenschaft und Werkstofftechnik. 2006, 37(6), pp. 441-445. ISSN 0933-5137. eISSN 1521-4052. Available under: doi: 10.1002/mawe.200600017
BibTex
@article{Sokolova2006Synth-40383,
  year={2006},
  doi={10.1002/mawe.200600017},
  title={Synthesis and characterization of DNA-functionalized calcium phosphate nanoparticles},
  number={6},
  volume={37},
  issn={0933-5137},
  journal={Materialwissenschaft und Werkstofftechnik},
  pages={441--445},
  author={Sokolova, V. and Prymak, O. and Meyer-Zaika, W. and Cölfen, Helmut and Rehage, H. and Shukla, A. and Epple, M.}
}
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