Structure of the oxygen adduct intermediate in the bacterialluciferase reaction : 13C nuclear magnetic resonance determination

Ghisla, Sandro; Hastings, J. Woodland; Favaudon, Vincent; Lhoste, Jean-Marc

Structure of the oxygen adduct intermediate in the bacterialluciferase reaction : 13C nuclear magnetic resonance determination

Dateien

1978_Ghisla_Structure_of_the_oxygen.pdfGröße: 959.56 KBDownloads: 211

Datum

1978

Autor:innen

Ghisla, Sandro

Hastings, J. Woodland

Favaudon, Vincent

Lhoste, Jean-Marc

URI (zitierfähiger Link)

http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-58352

Link zur Lizenz

Attribution-NonCommercial-NoDerivs 2.0 Generic

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Proceedings of the National Academy of Science of the United States of America. 1978, 75(12), pp. 5860-5863

Zusammenfassung

By using FMN enriched in 13C (90%) at position C-4a, we have conclusively shown that the reaction of molecular oxygen with bacterial luciferase-bound FMNH2 forms an adduct at the 4a position. Consistent with this are 13C NMR studies of FMN and other flavin compounds which show that this carbon should be unusually reactive in the reduced 1,5-dihydroflavins with respect to electrophilic attacks.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

subzero temperature, oxidation-reduction, substituted flavins, flavoproteins

Zitieren

ISO 690

GHISLA, Sandro, J. Woodland HASTINGS, Vincent FAVAUDON, Jean-Marc LHOSTE, 1978. Structure of the oxygen adduct intermediate in the bacterialluciferase reaction : 13C nuclear magnetic resonance determination. In: Proceedings of the National Academy of Science of the United States of America. 1978, 75(12), pp. 5860-5863

BibTex

@article{Ghisla1978Struc-7556,
  year={1978},
  title={Structure of the oxygen adduct intermediate in the bacterialluciferase reaction : 13C nuclear magnetic resonance determination},
  number={12},
  volume={75},
  journal={Proceedings of the National Academy of Science of the United States of America},
  pages={5860--5863},
  author={Ghisla, Sandro and Hastings, J. Woodland and Favaudon, Vincent and Lhoste, Jean-Marc}
}

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