Publikation:

Uncertainty of testing methods : What do we (want to) know?

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2013

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Paparella, Martin
Hornek-Gausterer, Romana
Kinzl, Maximilian
Mauritz, Ilse
Mühlegger, Simone

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Alternatives to Animal Experimentation : ALTEX. 2013, 30(2), pp. 131-144. ISSN 1868-596X. eISSN 1868-8551. Available under: doi: 10.14573/altex.2013.2.131

Zusammenfassung

It is important to stimulate innovation for regulatory testing methods. Scrutinizing the knowledge of (un)certainty of data from actual standard in vivo methods could foster the interest in new testing approaches. Since standard in vivo data often are used as reference data for model development, improved uncertainty accountability also would support the validation of new in vitro and in silico methods, as well as the definition of acceptance criteria for the new methods. Hazard and risk estimates, transparent for their uncertainty, could further support the 3Rs, since they may help focus additional information requirements on aspects of highest uncertainty. Here we provide an overview on the various types of uncertainties in quantitative and qualitative terms and suggest improving this knowledge base. We also reference principle concepts on how to use uncertainty information for improved hazard characterization and development of new testing methods.

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570 Biowissenschaften, Biologie

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ISO 690PAPARELLA, Martin, Mardas DANESHIAN, Romana HORNEK-GAUSTERER, Maximilian KINZL, Ilse MAURITZ, Simone MÜHLEGGER, 2013. Uncertainty of testing methods : What do we (want to) know?. In: Alternatives to Animal Experimentation : ALTEX. 2013, 30(2), pp. 131-144. ISSN 1868-596X. eISSN 1868-8551. Available under: doi: 10.14573/altex.2013.2.131
BibTex
@article{Paparella2013Uncer-38772,
  year={2013},
  doi={10.14573/altex.2013.2.131},
  title={Uncertainty of testing methods : What do we (want to) know?},
  number={2},
  volume={30},
  issn={1868-596X},
  journal={Alternatives to Animal Experimentation : ALTEX},
  pages={131--144},
  author={Paparella, Martin and Daneshian, Mardas and Hornek-Gausterer, Romana and Kinzl, Maximilian and Mauritz, Ilse and Mühlegger, Simone}
}
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