MDP and other muropeptides : direct and synergistic effects on the immune system

Traub, Stephanie; Aulock, Sonja von; Hartung, Thomas; Hermann, Corinna

MDP and other muropeptides : direct and synergistic effects on the immune system

Dateien

2006Traub_JER.pdfGröße: 1.58 MBDownloads: 801

Datum

2006

Autor:innen

Traub, Stephanie

Aulock, Sonja von

Hartung, Thomas

Hermann, Corinna

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie
Zukunftskolleg

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Journal of endotoxin research. 2006, 12(2), pp. 69-85. Available under: doi: 10.1177/09680519060120020301

Zusammenfassung

Muropeptides are breakdown products of peptidoglycan (PGN) of Gram-negative and Gram-positive bacteria. They are released during bacterial growth and division, as part of the host response by lysozyme and amidases, or upon antibiotic treatment. After phagocytosis of bacteria or bacterial breakdown products by host immune cells, the muropeptides trigger intracellular signaling cascades, leading to altered gene expression and activation of the immune response. Numerous muropeptides and derivatives have been synthesized chemically to characterize their immunostimulatory effects and adjuvant activity. Muramyl dipeptide, a natural partial structure of PGN, is the minimal structure with adjuvant activity. This review discusses the structure and occurrence of muropeptides and gives a broad overview of their inflammatory and adjuvant activity and the possible involvement of receptors in these responses.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Muropeptides, muramyl dipeptide, immune response, inflammation, adjuvant activity

Zitieren

ISO 690

TRAUB, Stephanie, Sonja von AULOCK, Thomas HARTUNG, Corinna HERMANN, 2006. MDP and other muropeptides : direct and synergistic effects on the immune system. In: Journal of endotoxin research. 2006, 12(2), pp. 69-85. Available under: doi: 10.1177/09680519060120020301

BibTex

@article{Traub2006other-8318,
  year={2006},
  doi={10.1177/09680519060120020301},
  title={MDP and other muropeptides : direct and synergistic effects on the immune system},
  number={2},
  volume={12},
  journal={Journal of endotoxin research},
  pages={69--85},
  author={Traub, Stephanie and Aulock, Sonja von and Hartung, Thomas and Hermann, Corinna}
}

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Universitätsbibliographie

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