Endotoxin elicits nitric oxide release in rat but prostacyclin synthesis in human and bovine vascular smooth muscle cells

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2005
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Bachschmid, Markus
Weber, Klaus
Maass, Dierk
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Biochemical and biophysical research communications. 2005, 327(1), pp. 43-48. ISSN 0006-291X. eISSN 1090-2104. Available under: doi: 10.1016/j.bbrc.2004.11.132
Zusammenfassung

Lipopolysaccharide (LPS) exposure to cells and tissues can mimic the biochemical events leading to septic shock. Previous data demonstrated a massive upregulation of prostaglandin endoperoxide H2 synthase (PGHS-2), but not NO synthase-2 (NOS-2) in bovine smooth muscle cells (SMC) between 2 and 12 h of LPS exposure. This caused an abundant release of prostacyclin (PGI2) by constitutive PGI2-synthase as a counterregulation to a dysfunctional endothelium. We here report that human as well as bovine SMC mainly respond by the induction of PGHS-2 and the subsequent release of PGI2, whereas rat SMC exhibited a distinct induction of NOS-2 and released significantly higher amounts of *NO compared with cattle and human. The induction of either PGHS-2 or NOS-2 in the three different species investigated seems to be mutually exclusive in the time window of 2-24 h. This finding should be considered in the setup of experimental models for the investigation of septic shock.

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ISO 690SCHILDKNECHT, Stefan, Markus BACHSCHMID, Klaus WEBER, Dierk MAASS, Volker ULLRICH, 2005. Endotoxin elicits nitric oxide release in rat but prostacyclin synthesis in human and bovine vascular smooth muscle cells. In: Biochemical and biophysical research communications. 2005, 327(1), pp. 43-48. ISSN 0006-291X. eISSN 1090-2104. Available under: doi: 10.1016/j.bbrc.2004.11.132
BibTex
@article{Schildknecht2005-02-04Endot-38359,
  year={2005},
  doi={10.1016/j.bbrc.2004.11.132},
  title={Endotoxin elicits nitric oxide release in rat but prostacyclin synthesis in human and bovine vascular smooth muscle cells},
  number={1},
  volume={327},
  issn={0006-291X},
  journal={Biochemical and biophysical research communications},
  pages={43--48},
  author={Schildknecht, Stefan and Bachschmid, Markus and Weber, Klaus and Maass, Dierk and Ullrich, Volker}
}
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