Publikation:

The "Sharp" blade against HIF-mediated metastasis

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Amelio_2-xwmsfu3fnipf4.pdf
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Datum

2012

Autor:innen

Melino, Gerry

Herausgeber:innen

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ISBN

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-xwmsfu3fnipf4
DOI (zitierfähiger Link)
https://doi.org/10.4161/cc.22820
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Urheberrechtlich geschützt

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Open Access-Veröffentlichung
Open Access Hybrid

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Biologie: Publikationen
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

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Zeitschriftenartikel
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Published

Erschienen in

Cell cycle. Taylor & Francis. 2012, 11(24), pp. 4530-4535. ISSN 1538-4101. eISSN 1551-4005. Available under: doi: 10.4161/cc.22820

Zusammenfassung

Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular reprograming that includes metabolism, proliferation, survival and mobility. HIFs overexpression in human cancer biopsies correlates with high metastasis and mortality. A recent report has elucidated a novel mechanism for HIFs regulation in triple-negative breast cancer. Specifically, the basic helix-loop-helix (bHLH), Sharp-1, serves HIF1α to the proteasome and promotes its O 2-indendpendet degradation, counteracting HIF-mediated metastasis. These findings shed light on how HIFs are manipulated during cancer pathogenesis.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

HIF, Sharp1, hypoxia, metastasis, cancer metabolism, breast cancer, angiogenesis, VHL, p63

Konferenz

Rezension
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ISO 690AMELIO, Ivano, Gerry MELINO, 2012. The "Sharp" blade against HIF-mediated metastasis. In: Cell cycle. Taylor & Francis. 2012, 11(24), pp. 4530-4535. ISSN 1538-4101. eISSN 1551-4005. Available under: doi: 10.4161/cc.22820
BibTex
@article{Amelio2012Sharp-57105,
  year={2012},
  doi={10.4161/cc.22820},
  title={The "Sharp" blade against HIF-mediated metastasis},
  number={24},
  volume={11},
  issn={1538-4101},
  journal={Cell cycle},
  pages={4530--4535},
  author={Amelio, Ivano and Melino, Gerry}
}
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