Exploitation of integrin function by pathogenic microbes

Numerous pathogens express adhesive proteins to directly or indirectly associate with integrins. It is well established that by targeting integrins, microbes not only establish an intimate contact with host tissues, but also trigger cellular responses including bacterial internalization. This review will summarize current knowledge about the role of these integrin-dependent processes during infection and how bacteria assure that they efficiently connect to integrins for host cell invasion or translocation of effector molecules. Furthermore, we will discuss recent insight demonstrating that bacteria can harness the physiological, matrix-binding function of integrins for promoting host colonization. From these combined studies, it is becoming evident that integrins are a common nexus for the manipulation of cellular functions by bacterial pathogens. Approaches to disrupt this connection might be an appropriate means to obtain broad-acting tools to modulate a spectrum of infectious diseases.

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HAUCK, Christof R., Marina BORISOVA, Petra MÜNZNER, 2012. Exploitation of integrin function by pathogenic microbes. In: Current Opinion in Cell Biology. 2012, 24(5), pp. 637-644. ISSN 0955-0674. eISSN 1879-0410. Available under: doi: 10.1016/j.ceb.2012.07.004

BibTex

@article{Hauck2012-10Explo-19998,
  year={2012},
  doi={10.1016/j.ceb.2012.07.004},
  title={Exploitation of integrin function by pathogenic microbes},
  number={5},
  volume={24},
  issn={0955-0674},
  journal={Current Opinion in Cell Biology},
  pages={637--644},
  author={Hauck, Christof R. and Borisova, Marina and Münzner, Petra}
}

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Exploitation of integrin function by pathogenic microbes