Publikation:

Genetic and environmental influence on DNA strand break repair : a twin study

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Garm_257062.pdf
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2013

Autor:innen

Garm, Christian
Larsen, Lisbeth A.
Bohr, Vilhelm A.
Christensen, Kaare
Stevnsner, Tinna

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http://nbn-resolving.de/urn:nbn:de:bsz:352-257062
DOI (zitierfähiger Link)
https://doi.org/10.1002/em.21791
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Biologie: Publikationen
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Published

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Environmental and Molecular Mutagenesis. 2013, 54(6), pp. 414-420. ISSN 0893-6692. eISSN 1098-2280. Available under: doi: 10.1002/em.21791

Zusammenfassung

Accumulation of DNA damage deriving from exogenous and endogenous sources has significant consequences for cellular survival, and is implicated in aging, cancer, and neurological diseases. Different DNA repair pathways have evolved in order to maintain genomic stability. Genetic and environmental factors are likely to influence DNA repair capacity. In order to gain more insight into the genetic and environmental contribution to the molecular basis of DNA repair, we have performed a human twin study, where we focused on the consequences of some of the most abundant types of DNA damage (single-strand breaks), and some of the most hazardous lesions (DNA double-strand breaks). DNA damage signaling response (Gamma-H2AX signaling), relative amount of endogenous damage, and DNA-strand break repair capacities were studied in peripheral blood mononuclear cells from 198 twins (94 monozygotic and 104 dizygotic). We did not detect genetic effects on the DNA-strand break variables in our study.

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570 Biowissenschaften, Biologie

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ISO 690GARM, Christian, Maria MORENO-VILLANUEVA, Alexander BÜRKLE, Lisbeth A. LARSEN, Vilhelm A. BOHR, Kaare CHRISTENSEN, Tinna STEVNSNER, 2013. Genetic and environmental influence on DNA strand break repair : a twin study. In: Environmental and Molecular Mutagenesis. 2013, 54(6), pp. 414-420. ISSN 0893-6692. eISSN 1098-2280. Available under: doi: 10.1002/em.21791
BibTex
@article{Garm2013-07Genet-25706,
  year={2013},
  doi={10.1002/em.21791},
  title={Genetic and environmental influence on DNA strand break repair : a twin study},
  number={6},
  volume={54},
  issn={0893-6692},
  journal={Environmental and Molecular Mutagenesis},
  pages={414--420},
  author={Garm, Christian and Moreno-Villanueva, Maria and Bürkle, Alexander and Larsen, Lisbeth A. and Bohr, Vilhelm A. and Christensen, Kaare and Stevnsner, Tinna}
}
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