Publikation: How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism
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2012
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Frontiers in immunology. 2012, 3, 167. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2012.00167
Zusammenfassung
T cell signaling begins with the ligation of the T cell antigen receptor (TCR) by a cognate peptide and the phosphorylation of the receptor's immunoreceptor tyrosine-based activation motif domains by the kinase Lck. However, the canonical receptor model is insufficient to explain how the constitutively active kinase Lck can discriminate between non-ligated and ligated TCRs. Here, we discuss the factors that are thought to regulate the spatial distribution of the TCR and Lck, and therefore critically influence TCR signaling initiation.
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570 Biowissenschaften, Biologie
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ROSSY, Jérémie, David J. WILLIAMSON, Katharina GAUS, 2012. How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism. In: Frontiers in immunology. 2012, 3, 167. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2012.00167BibTex
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year={2012},
doi={10.3389/fimmu.2012.00167},
title={How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism},
volume={3},
journal={Frontiers in immunology},
author={Rossy, Jérémie and Williamson, David J. and Gaus, Katharina},
note={Article Number: 167}
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