Publikation:

Investigations on the biotransformation capacity of organophosphates in the mollusc Dreissena polymorpha P.

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Dauberschmidt_1997283_294.pdf
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1997

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Dauberschmidt, Carole
Schlatter, Christian

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Aquatic toxicology. 1997, 37(4), pp. 283-294. ISSN 0166-445X. eISSN 1879-1514

Zusammenfassung

Microsomes of Dreissena polymorpha were able to biotransform the organophosphates thiometon and disulfoton significantly after 1 h incubation at 10 °C. Contrarily to vertebrates, biotransformation with mussel microsomes occurred without the addition of reduction equivalents (NADPH), at a considerably lower extent however. Metabolites of thiometon and disulfoton were detected with gas chromatography/mass spectrometry (GC/MS) analysis. The P450 content of whole mussel tissue was 8 pmol mg−1 protein being two orders of magnitude lower than the amounts measured in mammal liver. Ethoxycoumarin deethylase (ECOD) activity could be measured at 10 °C in microsomes of Dreissena (22 pmol min−1 mg−1 protein) but not at 37 °C. ECOD activity was inhibited in the presence of NADPH (measured activity 3 pmol min−1 mg−1).

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Dreissena polymorpha, Mixed-function oxygenase (MFO), Cytochrome P450, ECOD activity, Organophosphate metabolism

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ISO 690DAUBERSCHMIDT, Carole, Daniel R. DIETRICH, Christian SCHLATTER, 1997. Investigations on the biotransformation capacity of organophosphates in the mollusc Dreissena polymorpha P.. In: Aquatic toxicology. 1997, 37(4), pp. 283-294. ISSN 0166-445X. eISSN 1879-1514
BibTex
@article{Dauberschmidt1997Inves-6721,
  year={1997},
  title={Investigations on the biotransformation capacity of organophosphates in the mollusc Dreissena polymorpha P.},
  number={4},
  volume={37},
  issn={0166-445X},
  journal={Aquatic toxicology},
  pages={283--294},
  author={Dauberschmidt, Carole and Dietrich, Daniel R. and Schlatter, Christian}
}
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