Publikation: Investigations on the biotransformation capacity of organophosphates in the mollusc Dreissena polymorpha P.
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Microsomes of Dreissena polymorpha were able to biotransform the organophosphates thiometon and disulfoton significantly after 1 h incubation at 10 °C. Contrarily to vertebrates, biotransformation with mussel microsomes occurred without the addition of reduction equivalents (NADPH), at a considerably lower extent however. Metabolites of thiometon and disulfoton were detected with gas chromatography/mass spectrometry (GC/MS) analysis. The P450 content of whole mussel tissue was 8 pmol mg−1 protein being two orders of magnitude lower than the amounts measured in mammal liver. Ethoxycoumarin deethylase (ECOD) activity could be measured at 10 °C in microsomes of Dreissena (22 pmol min−1 mg−1 protein) but not at 37 °C. ECOD activity was inhibited in the presence of NADPH (measured activity 3 pmol min−1 mg−1).
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DAUBERSCHMIDT, Carole, Daniel R. DIETRICH, Christian SCHLATTER, 1997. Investigations on the biotransformation capacity of organophosphates in the mollusc Dreissena polymorpha P.. In: Aquatic toxicology. 1997, 37(4), pp. 283-294. ISSN 0166-445X. eISSN 1879-1514BibTex
@article{Dauberschmidt1997Inves-6721, year={1997}, title={Investigations on the biotransformation capacity of organophosphates in the mollusc Dreissena polymorpha P.}, number={4}, volume={37}, issn={0166-445X}, journal={Aquatic toxicology}, pages={283--294}, author={Dauberschmidt, Carole and Dietrich, Daniel R. and Schlatter, Christian} }
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