Nucleotides part LXXX : Synthesis of 3′-O fluorescence labeled thymidine derivatives and their 5′-O-triphosphates

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2011
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Prykota, Tamara I.
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A new labeling technique attaching a fluorescent pteridine derivative (3, 5) via a linker onto the 3′-OH group of 5′-O-dimethoxytritylthymidine (7) was developed to lead to the conjugates 8 and 11. After detritylation to give 9 and 12, the final conversion into the corresponding 5′-triphosphates (13, 14), which were isolated as sodium salts, was performed by known methods.

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540 Chemie
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isoxanthopterin derivatives, fluorescent marker, thymidine conjugates, nucleoside 5′-triphosphates
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ISO 690PRYKOTA, Tamara I., Wolfgang PFLEIDERER, 2011. Nucleotides part LXXX : Synthesis of 3′-O fluorescence labeled thymidine derivatives and their 5′-O-triphosphates. In: Nucleosides, Nucleotides and Nucleic Acids. 2011, 30(7-8), pp. 544-551. ISSN 1525-7770. eISSN 1532-2335. Available under: doi: 10.1080/15257770.2011.578089
BibTex
@article{Prykota2011-07Nucle-19904,
  year={2011},
  doi={10.1080/15257770.2011.578089},
  title={Nucleotides part LXXX : Synthesis of 3′-O fluorescence labeled thymidine derivatives and their 5′-O-triphosphates},
  number={7-8},
  volume={30},
  issn={1525-7770},
  journal={Nucleosides, Nucleotides and Nucleic Acids},
  pages={544--551},
  author={Prykota, Tamara I. and Pfleiderer, Wolfgang}
}
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