VisExpress : Visual exploration of differential gene expression data

Simon, Svenja; Mittelstädt, Sebastian; Kwon, Bum Chul; Stoffel, Andreas; Landstorfer, Richard; Neuhaus, Klaus; Mühlig, Anna; Scherer, Siegfried; Keim, Daniel A.

VisExpress : Visual exploration of differential gene expression data

Dateien

Simon_0-312302.pdfGröße: 8.7 MBDownloads: 302

Datum

2017

Autor:innen

Simon, Svenja

Mittelstädt, Sebastian

Kwon, Bum Chul

Stoffel, Andreas

Landstorfer, Richard

Neuhaus, Klaus

Mühlig, Anna

Scherer, Siegfried

Keim, Daniel A.

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Information Visualization. 2017, 16(1), pp. 48-73. ISSN 1473-8716. eISSN 1473-8724. Available under: doi: 10.1177/1473871615612883

Zusammenfassung

Biologists are keen to understand how processes in cells react to environmental changes. Differential gene expression analysis allows biologists to explore functions of genes with data generated from different environments. However, these data and analysis lead to unique challenges since tasks are ill-defined, require implicit domain knowledge, comprise large volumes of data, and are, therefore, of explanatory nature. To investigate a scalable visualization-based solution, we conducted a design study with three biologists specialized in differential gene expression analysis. We stress our contributions in three aspects: first, we characterize the problem domain for exploring differential gene expression data and derive task abstractions and design requirements. Second, we investigate the design space and present an interactive visualization system, called VisExpress. Third, we evaluate the usefulness of VisExpress via a Pair Analytics study with real users and real data and report on insights that were gained by our experts with VisExpress.

Fachgebiet (DDC)

004 Informatik

Schlagwörter

Information visualization, design study, bioinformatics visualization, interactive visual exploration, biological data, expression data, gene expression profiling, differential gene expression

Zitieren

ISO 690

SIMON, Svenja, Sebastian MITTELSTÄDT, Bum Chul KWON, Andreas STOFFEL, Richard LANDSTORFER, Klaus NEUHAUS, Anna MÜHLIG, Siegfried SCHERER, Daniel A. KEIM, 2017. VisExpress : Visual exploration of differential gene expression data. In: Information Visualization. 2017, 16(1), pp. 48-73. ISSN 1473-8716. eISSN 1473-8724. Available under: doi: 10.1177/1473871615612883

BibTex

@article{Simon2017-01VisEx-32512,
  year={2017},
  doi={10.1177/1473871615612883},
  title={VisExpress : Visual exploration of differential gene expression data},
  number={1},
  volume={16},
  issn={1473-8716},
  journal={Information Visualization},
  pages={48--73},
  author={Simon, Svenja and Mittelstädt, Sebastian and Kwon, Bum Chul and Stoffel, Andreas and Landstorfer, Richard and Neuhaus, Klaus and Mühlig, Anna and Scherer, Siegfried and Keim, Daniel A.}
}

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Universitätsbibliographie

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