Publikation:

Perspective on multi-target antiplatelet therapies : high content phenotypic screening as an unbiased source of novel polypharmacological strategies

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2015

Autor:innen

Landré, Vivien
Barlev, Nick A.
Knight, Richard A.
Lisitsa, Andrey
Melino, Gerry
Antonov, Alexey V.

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https://doi.org/10.2174/1389557515666150219124018
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Biologie: Publikationen
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Mini reviews in medicinal chemistry. Bentham Science. 2015, 15(8), pp. 622-629. ISSN 1389-5575. eISSN 1875-5607. Available under: doi: 10.2174/1389557515666150219124018

Zusammenfassung

Platelets play an important role in cardiovascular thrombosis as well as in many other pathological conditions such as inflammation, atherosclerosis and cancer. While multi-target strategies to treat complex diseases are gaining considerable attention, current development of antiplatelet therapies is mostly oriented towards several single targets, arising from our present understanding of the regulation of platelet activation. Limited efforts to develop multi-target agents or multidrug therapies are mostly due to a lack of a systematic basis to define target combinations with synergistic effects. Here we discuss the perspective to use high content phenotypic screening of in vitro models as a potential source for inference of synergetic multi-target strategies to control platelet activation.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Antiplatelet therapies, CASP3, COX1, high content screening, KLF5, multi-target therapies, NPC1, PKM, polypharmacology, platelets, SENP6, TNFSF10, SENP

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ISO 690LANDRÉ, Vivien, Ivano AMELIO, Nick A. BARLEV, Richard A. KNIGHT, Andrey LISITSA, Gerry MELINO, Alexey V. ANTONOV, 2015. Perspective on multi-target antiplatelet therapies : high content phenotypic screening as an unbiased source of novel polypharmacological strategies. In: Mini reviews in medicinal chemistry. Bentham Science. 2015, 15(8), pp. 622-629. ISSN 1389-5575. eISSN 1875-5607. Available under: doi: 10.2174/1389557515666150219124018
BibTex
@article{Landre2015Persp-57075,
  year={2015},
  doi={10.2174/1389557515666150219124018},
  title={Perspective on multi-target antiplatelet therapies : high content phenotypic screening as an unbiased source of novel polypharmacological strategies},
  number={8},
  volume={15},
  issn={1389-5575},
  journal={Mini reviews in medicinal chemistry},
  pages={622--629},
  author={Landré, Vivien and Amelio, Ivano and Barlev, Nick A. and Knight, Richard A. and Lisitsa, Andrey and Melino, Gerry and Antonov, Alexey V.}
}
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